Synthesis of C2-C4 diols from bioresources: Pathways and metabolic intervention strategies. (February 2022)

• Record Type: Journal Article
• Authors: Paul Alphy, Maria; Hakkim Hazeena, Sulfath; Binoop, Mohan; Madhavan, Aravind; Arun, K.B.; Vivek, Narisetty; Sindhu, Raveendran; Kumar Awasthi, Mukesh; Binod, Parameswaran
• Is Part Of: Bioresource technology. Volume 346(2022)
• Publication Date: 2022-02
• Subjects: Synthetic biology -- Bioresources -- Ethylene glycol -- Propanediol -- Butanediol; Biomass -- Periodicals; Biomass energy -- Periodicals; Bioremediation -- Periodicals; Agricultural wastes -- Periodicals; Factory and trade waste -- Periodicals; Organic wastes -- Periodicals; Bioénergie -- Périodiques; Déchets agricoles -- Périodiques; Déchets industriels -- Périodiques; Déchets organiques -- Périodiques; Déchets (Combustible) -- Périodiques; 662.88
• DOI: 10.1016/j.biortech.2021.126410
• Languages: English
• ISSNs: 0960-8524

Abstract

Graphical abstract: Highlights: C2-C4 diols produced from renewable resources- byproducts of petroleum industry. Natural and synthetic metabolic pathways for diol production are discussed. Overview of latest strategies for environmentally safe diol production. Abstract: Diols are important platform chemicals with extensive industrial applications in biopolymer synthesis, cosmetics, and fuels. The increased dependence on non-renewable sources to meet the energy requirement of the population raised issues regarding fossil fuel depletion and environmental impacts. The utilization of biological methods for the synthesis of diols by utilizing renewable resources such as glycerol and agro-residual wastes gained attention worldwide because of its advantages. Among these, biotransformation of 1, 3-propanediol (1, 3-PDO) and 2, 3-butanediol (2, 3-BDO) were extensively studied and at present, these diols are produced commercially in large scale with high yield. Many important isomers of C2-C4 diols lack natural synthetic pathways and development of chassis strains for the synthesis can be accomplished by adopting synthetic biology approaches. This current review depicts an overall idea about the pathways involved in C2-C4 diol production, metabolic intervention strategies and technologies in recent years.