A review on mechanical and In-vitro studies of polymer reinforced bioactive glass-scaffolds and their fabrication techniques. Issue 5 (1st March 2022)

• Record Type: Journal Article
• Authors: Jain, Satish; Gujjala, Raghavendra; Abdul Azeem, P.; Ojha, Shakuntala; Samudrala, Raj Kumar
• Is Part Of: Ceramics international. Volume 48:Issue 5(2022)
• Page Start: 5908
• Page End: 5921
• Publication Date: 2022-03-01
• Subjects: Polymer -- Bio-active glass -- Scaffold -- Tissue engineering; Ceramics -- Periodicals; Céramique industrielle -- Périodiques; Ceramics; Periodicals; Electronic journals; 666
• DOI: 10.1016/j.ceramint.2021.11.206
• Languages: English
• ISSNs: 0272-8842

Abstract

Abstract: Over the last few decades, extensive research has been carried out in the field of bioactive scaffolds as replacement material in bone-tissue engineering. The scaffolds have been fabricated employing a combination of biodegradable polymers (due to their biocompatibility and adaptive degradation) and bioactive glass (to impart strength and bioactivity). In this review, a detailed study on the mechanical behavior of polymer-bioactive glass scaffold has been conducted, revealing insufficient strength compared to human cortical bone. The impact of ceramic filler content on the in-vitro bioactivity and biodegradability of scaffold have been discussed. Finally, the rationale and approach for fabricating these 3-D scaffolds with well-distributed and interconnected pores have been reviewed. Graphical abstract: Image 1 Highlights: The manuscript emphasizes on the mechanical and in-vitro study of polymer reinforced bioactive glass-scaffolds. Different scaffold fabrication techniques have also been discussed. Porosity and pore interconnectivity are an integral part of any scaffold to ensure diffusion of Oxygen and cell nutrients. The incorporation of bioactive glass in polymer improves its mechanical stability and biological properties.