Chemical composition, Evaluation of Antiparasitary and Cytotoxic Activity of the essential oil of Psidium brownianum MART EX. DC. (January 2022)

• Record Type: Journal Article
• Authors: Bezerra, Jéssica Nogueira; Gomez, Maria Celeste Vega; Rolón, Míriam; Coronel, Cathia; Almeida-Bezerra, José Weverton; Fidelis, Kleber Ribeiro; Menezes, Saulo Almeida de; Cruz, Rafael Pereira da; Duarte, Antônia Eliene; Ribeiro, Paulo Riceli Vasconcelos; Brito, Edy Sousa de; Coutinho, Henrique Douglas Melo; Morais-Braga, Maria Flaviana Bezerra; Bezerra, Camila Fonseca
• Is Part Of: Biocatalysis and agricultural biotechnology. Number 39(2022)
• Publication Date: 2022-01
• Subjects: Anti-kinetoplastid -- Phytochemistry -- Cytotoxicity -- Myrtaceae; Agricultural biotechnology -- Periodicals; Enzymes -- Biotechnology -- Periodicals; 660.6
• DOI: 10.1016/j.bcab.2021.102247
• Languages: English
• ISSNs: 1878-8181

Abstract

Abstract: Chagas Disease and Leishmaniasis are neglected parasitic diseases that constitute a major public health problem. In the search for new therapeutic alternatives for such pathologies, the essential oil of the leaves of Psidium brownianum Mart ex DC was investigated regarding its chemical composition, antiparasitic, and cytotoxic effects. The chemical composition of the oil was analyzed by gas chromatography coupled to mass spectrometry (GC/MS), showing two major constituents: Isogermafurene (52.93%) and Germacrone (16.02%). In antiparasitic activity, the oil was tested against the epimastigote forms of Trypanosoma cruzi, revealing 57.05% inhibition at the highest tested concentration (1000 μg/mL). In regard to antiparasitic activity against promastigote forms of Leishmania braziliensis and Leishmania infantum, it obtained 92.61% and 84.16% inhibition, respectively, at the highest concentrations (1000 μg/mL). As for the cytotoxic effects, it showed high cytotoxicity, with IC50 = 328.9 μg/mL. The inhibitory concentration (IC50 ) obtained the best result for the promastigote forms of L. braziliensis (IC50 = 37.53 μg/mL), as well as the selectivity index (SI = 8.76). Such results generate perspectives for new research and may contribute to more effective drug discoveries. Highlights: The essential oil (OE) of Psidium brownianum has an antiparasitic effect. The EO of P. brownianum shows cytotoxicity against fibroblasts. The EO of P. brownianum presents Isogermafurene as a major compound. Only sesquiterpenes are present in the said natural product.