Hibiscus manihot L improves obesity in mice induced by a high-fat diet. (February 2022)

• Record Type: Journal Article
• Authors: Chen, Shanshan; Xu, Minglu; Zhou, Min; He, Yingxin; Li, Yongchun; Lang, Hui; Wei, Xuliang; Yan, Lijie; Xu, Hongde
• Is Part Of: Journal of functional foods. Volume 89(2022)
• Publication Date: 2022-02
• Subjects: Hibiscus manihot L -- Obesity -- Brown adipose tissue -- UCP1 -- Gut microbiota; Functional foods -- Analysis -- Periodicals; Food -- Biotechnology -- Periodicals; Nutrition -- Periodicals; 613.2
• DOI: 10.1016/j.jff.2022.104953
• Languages: English
• ISSNs: 1756-4646

Abstract

Graphical abstract: Highlights: Hibiscus manihot L can reduce obesity caused by a high-fat diet. Hibiscus manihot L increases brown adipose tissue thermogenesis by activating UCP1. Hibiscus manihot L induces the browning of white fat. Hibiscus manihot L regulates the expression of adipokines. Hibiscus manihot L changes the abundance of Mucispirillum sp 69 in the intestine. Abstract: Hibiscus manihot L (HM) is a natural plant that contains a variety of biologically active ingredients, but its role in obesity is unknown. The purpose of this study was to explore the anti-obesity activity of HM and its related mechanisms. 3T3-L1 mouse preadipocytes were used to test the anti-adipogenic activity of HM. Feeding mice on a high-fat diet with HM for 10 weeks reduced the obesity and insulin resistance of the mice. HM upregulated the expression of uncoupling protein 1 (UCP1) and thermogenesis genes and increased the abundance of Mucispirillum sp 69. In conclusion, HM may reduce obesity of mice induced by a high-fat diet by changing the composition of the gut microbiota, activating UCP1 to increase the thermogenesis of brown fat and inducing the browning of white fat. Thus, HM may be a potential drug for the treatment of obesity.