Evaluation of the effect of bone plate modulus on the early bone healing of fractured tibia. (15th March 2022)

• Record Type: Journal Article
• Authors: Zaheer, Muhammad Usama; Mehboob, Hassan; Mehboob, Ali; Chang, Seung-Hwan
• Is Part Of: Composites. Number 233(2022)
• Publication Date: 2022-03-15
• Subjects: A. polymer-matrix composites (PMCs) -- A. Carbon fibre -- C. Computational modelling -- C. Finite element analysis (FEA); Composite materials -- Periodicals; Materials science -- Periodicals; Composite materials; Periodicals; Electronic journals; 620.118
• DOI: 10.1016/j.compositesb.2022.109668
• Languages: English
• ISSNs: 1359-8368

Abstract

Abstract: Metallic implants with high Young's moduli are used to treat long-bone fractures; however, they cause stress shielding and prevent bones from attaining their original strength. Thus, flexible composite implants have been designed to enhance tissue development without stress shielding. Herein, 3D-printed composite bone plates with different Young's moduli were designed, and their effects on 3D models of long-bone fractures were analysed. A biphasic mechano-regulation algorithm, coupled with cell diffusion and tissue phenotype activities, was developed using a Python script to analyse bone-healing patterns for 112 days after surgery. A composite bone plate (Young's modulus, 40 GPa) showed the best healing performance (100%), compared with a stainless-steel bone plate (70%). Further, cell and tissue development using bone plates with different Young's moduli under different loading conditions are presented. Graphical abstract: Image 1