Effects of blue honeysuckle containing anthocyanin on anti-diabetic hypoglycemia and hyperlipidemia in ob/ob mice. (February 2022)

• Record Type: Journal Article
• Authors: Lee, Hyun Jeong; Lee, Da-Yeon; Chun, Yoon-Seok; Kim, Jong-Kyu; Lee, Jung-Ok; Ku, Sae-Kwang; Shim, Soon-Mi
• Is Part Of: Journal of functional foods. Volume 89(2022)
• Publication Date: 2022-02
• Subjects: Blue honeysuckle -- Anti-diabetic -- Non-alcoholic fatty liver disease -- Hyperlipidemia -- AMP-activated protein kinase; α-SMA α-smooth muscle actin -- ABC avidin-biotin complex -- ACC acetyl-CoA carboxylase -- AMPK 5′ adenosine monophosphate-activated protein kinase -- BH blue honeysuckle -- C/EBP CCAAT-enhancer-binding protein -- CLA conjugated linoleic acid -- DEXA dual-energy x-ray absorptiometry -- H&E hematoxylin and eosin -- HPLC high performance of liquid chromatography -- MMP matrix metalloprotein -- MW Mann-Whitney U -- NAFLD non-alcoholic fatty liver disease -- PBS phosphate buffer saline -- PPAR peroxisome proliferator activating receptor -- RT-PCR reverse transcription polymerase chain reaction -- SD standard deviation -- SREBP sterol regulatory element-binding protein -- TG triglyceride -- TGF transforming growth factor -- UCP mitochondrial uncoupling protein -- UV ultraviolet; Functional foods -- Analysis -- Periodicals; Food -- Biotechnology -- Periodicals; Nutrition -- Periodicals; 613.2
• DOI: 10.1016/j.jff.2022.104959
• Languages: English
• ISSNs: 1756-4646

Abstract

Graphical abstract: Highlights: BH extracts showed anti-obesity effects by downregulating PPARγ expressions. BH extracts improved anti-diabetic complications via AMPK upregulations. BH extracts regulated lipid metabolism-related gene expressions. BH extracts is a potential ingredient for anti-obese medicinal food in the future. Abstract: The purpose of the current study was to observe the anti-diabetic and anti-obesity effects of blue honeysuckle (BH; Lonicera caerulea L.) extracts on obese diabetic mice. BH extracts dose-dependently and significantly inhibited abnormal endocrine pancreas histopathological changes. Moreover, favorable anti-diabetic effects and non-alcoholic fatty liver disease, nephropathy, and hyperlipidemia refinement activities in BH extracts were shown to be dose dependent. Particularly, BH extract 200 mg/kg showed favorable modulatory activities on PPAR γ and AMPK in hepatic and adipose tissues as comparable to those of positive control, conjugated linoleic acid (CLA) administration. Results from the current study suggest that BH extracts could be a potential functional ingredient for anti-obesity and anti-diabetic effects through the inhibition of lipogenesis and hepatic glucose production by regulating lipid metabolism-related mRNA expressions.