Trends in valorization of highly-toxic lignocellulosic biomass derived-compounds via engineered microbes. (February 2022)

• Record Type: Journal Article
• Authors: Jayakody, Lahiru N.; Chinmoy, Baroi; Turner, Timothy L.
• Is Part Of: Bioresource technology. Volume 346(2022)
• Publication Date: 2022-02
• Subjects: Toxicant -- Biofunneling -- Tolerance engineering -- Platform chemicals -- Chemo-biological valorization; Biomass -- Periodicals; Biomass energy -- Periodicals; Bioremediation -- Periodicals; Agricultural wastes -- Periodicals; Factory and trade waste -- Periodicals; Organic wastes -- Periodicals; Bioénergie -- Périodiques; Déchets agricoles -- Périodiques; Déchets industriels -- Périodiques; Déchets organiques -- Périodiques; Déchets (Combustible) -- Périodiques; 662.88
• DOI: 10.1016/j.biortech.2021.126614
• Languages: English
• ISSNs: 0960-8524

Abstract

Graphical abstract: Highlights: Lignocellulosic biomass-derived chemicals pose toxicity on microbes. Macromolecules protections are vital for tolerance engineering of microbes. Key metabolic routes are highlighted to biofunnel biomass-derived toxic chemicals. Robust synthetic microbes can valorize toxic chemicals to platform chemicals. Bioconversion of toxic chemicals enhances economic benefits to biorefineries. Abstract: Lignocellulosic biomass-derived fuels, chemicals, and materials are promising sustainable solutions to replace the current petroleum-based production. The direct microbial conversion of thermos-chemically pretreated lignocellulosic biomass is hampered by the presence of highly toxic chemical compounds. Also, thermo-catalytic upgrading of lignocellulosic biomass generates wastewater that contains heterogeneous toxic chemicals, a mixture of unutilized carbon. Metabolic engineering efforts have primarily focused on the conversion of carbohydrates in lignocellulose biomass; substantial opportunities exist to harness value from toxic lignocellulose-derived toxic compounds. This article presents the comprehensive metabolic routes and tolerance mechanisms to develop robust synthetic microbial cell factories to valorize the highly toxic compounds to advanced-platform chemicals. The obtained platform chemicals can be used to manufacture high-value biopolymers and biomaterials via a hybrid biochemical approach for replacing petroleum-based incumbents. The proposed strategy enables a sustainable bio-based materials economy by microbial biofunneling of lignocellulosic biomass-derived toxic molecules, an untapped biogenic carbon.