Forced into shape: Mechanical forces in Drosophila development and homeostasis. (December 2021)

• Record Type: Journal Article
• Authors: Paci, Giulia; Mao, Yanlan
• Is Part Of: Seminars in cell & developmental biology. Volume 120(2021)
• Page Start: 160
• Page End: 170
• Publication Date: 2021-12
• Subjects: Mechanical forces -- Drosophila development -- Morphogenesis -- Patterning -- Homeostasis; Cytology -- Periodicals; Developmental biology -- Periodicals; 571.6
• DOI: 10.1016/j.semcdb.2021.05.026
• Languages: English
• ISSNs: 1084-9521

Abstract

Abstract: Mechanical forces play a central role in shaping tissues during development and maintaining epithelial integrity in homeostasis. In this review, we discuss the roles of mechanical forces in Drosophila development and homeostasis, starting from the interplay of mechanics with cell growth and division. We then discuss several examples of morphogenetic processes where complex 3D structures are shaped by mechanical forces, followed by a closer look at patterning processes. We also review the role of forces in homeostatic processes, including cell elimination and wound healing. Finally, we look at the interplay of mechanics and developmental robustness and discuss open questions in the field, as well as novel approaches that will help tackle them in the future.