Mechanics of epidermal morphogenesis in the Drosophila pupa. (December 2021)

• Record Type: Journal Article
• Authors: Athilingam, Thamarailingam; Tiwari, Prabhat; Toyama, Yusuke; Saunders, Timothy E.
• Is Part Of: Seminars in cell & developmental biology. Volume 120(2021)
• Page Start: 171
• Page End: 180
• Publication Date: 2021-12
• Subjects: Metamorphosis -- Imaginal discs -- Histoblast nest -- Larval epidermis -- Tissue mechanics; Cytology -- Periodicals; Developmental biology -- Periodicals; 571.6
• DOI: 10.1016/j.semcdb.2021.06.008
• Languages: English
• ISSNs: 1084-9521

Abstract

Abstract: Adult epidermal development in Drosophila showcases a striking balance between en masse spreading of the developing adult precursor tissues and retraction of the degenerating larval epidermis. The adult precursor tissues, driven by both intrinsic plasticity and extrinsic mechanical cues, shape the segments of the adult epidermis and appendages. Here, we review the tissue architectural changes that occur during epidermal morphogenesis in the Drosophila pupa, with a particular emphasis on the underlying mechanical principles. We highlight recent developments in our understanding of adult epidermal morphogenesis. We further discuss the forces that drive these morphogenetic events and finally outline open questions and challenges.