A bionic cellulose nanofiber-based nanocage wound dressing for NIR-triggered multiple synergistic therapy of tumors and infected wounds. (February 2022)

• Record Type: Journal Article
• Authors: Chen, Rimei; Zhao, Chao; Chen, Zhiping; Shi, Xiaoyu; Zhu, Hongxiang; Bu, Qing; Wang, Lei; Wang, Chunfang; He, Hui
• Is Part Of: Biomaterials. Volume 281(2022)
• Publication Date: 2022-02
• Subjects: Cellulose nanofibers -- Near infrared-triggered -- Wound dressing -- Synergistic therapy -- Infected wound; Biomedical materials -- Periodicals; Biocompatible Materials -- Periodicals; Biomatériaux -- Périodiques; 610.28
• DOI: 10.1016/j.biomaterials.2021.121330
• Languages: English
• ISSNs: 0142-9612

Abstract

Abstract: Tumor recurrence and drug-resistant bacterial infection are the main reasons that wounds heal with difficulty after skin tumor treatment. The near infrared- (NIR-) and pH-responsive, bionic, cellulose nanofiber-based (CNF-based) nanocage wound dressing with biocompatibility, bioviscosity, and shape adaptability is designed for dual NIR-triggered photothermal therapy of tumor and infection-induced wound healing. The wound dressing with the intertwining three dimensional (3D) nanocage network structure is skillfully constructed using NIR-responsive cellulose nanofibers and pH-responsive cellulose nanofibers as the skeleton, which endows the dressing with a high drug-loading capacity of doxorubicin (400 mg·g -1 ), and indocyanine green (25 mg·g - 1 ). Moreover, the NIR- and pH-responsive bionic "On/Off" switches of the dressing enable a controllable and efficient drug release onto the wound area. The dual NIR-triggered wound dressing with excellent photothermal conversion performance possesses good antibacterial properties against Escherichia coli, Staphylococcus aureus, and drug-resistant Staphylococcus aureus . It could effectively eliminate bacterial biofilms and kill A375 tumor cells. Interestingly, the bionic wound dressing with shape adaptability could adapt and treat irregular postoperative skin tumor wounds and drug-resistant bacterial infection via the synergistic therapy of photothermal, photodynamic, and chemotherapy, which provides an ideal strategy for clinical intervention. Graphical abstract: Image 1