Efficient exosome extraction through the conjugation of superparamagnetic iron oxide nanoparticles for the targeted delivery in rat brain. (March 2022)

• Record Type: Journal Article
• Authors: Wang, J.; Zhu, X.; Li, C.; Cai, L.; Pei, W.; Ni, M.; He, J.; Jiang, H.; Chen, J.
• Is Part Of: Materials today chemistry. Volume 23(2022)
• Publication Date: 2022-03
• Subjects: Transferrin -- Drug delivery -- Magnetic targeting ability -- Blood-brain barriers; Chemistry -- Periodicals; Materials -- Research -- Periodicals; Materials science -- Periodicals; Chemistry; Materials -- Research; Electronic journals; Periodicals; 660.282
• DOI: 10.1016/j.mtchem.2021.100637
• Languages: English
• ISSNs: 2468-5194

Abstract

Abstract: Exosomes possess endogenous attributes and distinct biological functions, and thereby, their uses as drug nanocarriers have attracted increasing attention for biomedical practices. However, to achieve targeted therapeutic purposes, complicated extractions, as well as modifications of exosomes, are involved. Here, based on the use of superparamagnetic iron oxide nanoparticles conjugated exosome (Ex-SPIONs), a facile exosome extraction through magnetism was established. The produced Ex-SPIONs exhibited a uniform size distribution and desirable biocompatibility. Moreover, taking advantage of the magnetic properties of SPIONs, the targeted delivery of Ex-SPIONs was demonstrated in the rat brain. Therefore, the constructed SPIONs functionalized exosome shows promising therapeutic potentials, including the treatment of brain diseases. Graphical abstract: Facile isolation of exosome-SPIONs conjugates for the targeted delivery in the cell and in rats brain. Image 1 Highlights: PEGlyated superparamagnetic iron oxide nanoparticles (PEG-SPIONs) are synthesized to conjugate transferrin (Tf). SPIONs modified exosomes (Ex-SPIONs) are formed via the interaction of Tf-SPIONs and Tf receptors of exosomes. Ex-SPIONs exhibit a uniform size distribution and desirable biocompatibility. The targeted delivery of Ex-SPIONs is demonstrated in the rat brain.