Trend analysis of carbapenem-resistant Gram-negative bacteria and antimicrobial consumption in the post-COVID-19 era: an extra challenge for healthcare institutions. (February 2022)

• Record Type: Journal Article
• Authors: de Carvalho Hessel Dias, V.M.; Tuon, F.; de Jesus Capelo, P.; Telles, J.P.; Fortaleza, C.M.C.B.; Pellegrino Baena, C.
• Is Part Of: Journal of hospital infection. Volume 120(2022)
• Page Start: 43
• Page End: 47
• Publication Date: 2022-02
• Subjects: Healthcare-associated infections -- Acinetobacter baumannii -- Antimicrobial drug resistance -- COVID-19 -- Carbapenems -- Polymyxins; Cross infection -- Periodicals; Cross infection -- Prevention -- Periodicals; Nosocomial infections -- Periodicals; Nosocomial infections -- Prevention -- Periodicals; Cross Infection -- Periodicals; Cross Infection -- prevention & control -- Periodicals; Infection Control -- Periodicals; Electronic journals; 614.44
• DOI: 10.1016/j.jhin.2021.11.011
• Languages: English
• ISSNs: 0195-6701

Abstract

Summary: The incidence density trend of the carbapenem-resistant Gram-negative bacteria was analysed in device-associated infections and antimicrobial consumption in 99 critical care facilities in a low/middle-income country, between January 2019 and December 2020. Carbapenem-resistant Acinetobacter baumannii (CRAB) per 1000 patient-days increased in 2020 and this finding had a strong positive correlation with the incidence density of COVID-19 by the Spearman test. Polymyxin consumption also increased in 2020 but without significant correlation with CRAB or COVID-19 incidence density, presumably due to empirical and untargeted prescribing as a consequence of concern about CRAB infections. These findings are a warning to infection control programmes and antimicrobial stewardship.