Detailed comparison of anatomy and airflow dynamics in human and cynomolgus monkey nasal cavity. (February 2022)

• Record Type: Journal Article
• Authors: Tian, Lin; Dong, Jingliang; Shang, Yidan; Tu, Jiyuan
• Is Part Of: Computers in biology and medicine. Volume 141(2022)
• Publication Date: 2022-02
• Subjects: Human nasal cavity -- Monkey nasal cavity -- Interspecies extrapolation -- Airflow dynamics -- Morphometry analysis -- Computational fluid dynamics; Medicine -- Data processing -- Periodicals; Biology -- Data processing -- Periodicals; 610.285
• DOI: 10.1016/j.compbiomed.2021.105150
• Languages: English
• ISSNs: 0010-4825

Abstract

Abstract: Nonhuman primates are occasionally used as laboratory models for sophisticated medical research as they bear the closest resemblance to humans in morphometry and physiological functions. A range of nonhuman primate species have been employed in the inhalation toxicity, nasal drug delivery and respiratory viral infection studies, and they provided valuable insight to disease pathogenesis while other laboratory animals such as rodents cannot recapitulate due to the lesser degree of similarity in metabolism, anatomy and cellular response to that of humans. It is anticipated that nonhuman primate models of respiratory diseases will continue to be instrumental for translating biomedical research for improvement of human health, and the confidence in laboratory data extrapolation between species will play a pivotal role. From the morphometry and flow dynamics point of view, this study performed a detailed comparative analysis between human and a cynomolgus monkey nasal airway, with intention to provide high-fidelity qualitative and quantitative linkage between the two species for more effective laboratory data extrapolation. The study revealed that cynomolgus monkey could be a good human surrogate in nasal inhalation studies; however, care should be given for interspecies data extrapolation as subtle differences in anatomy and airflow dynamics were present between the two species. Highlights: Detailed comparative analysis between human and a cynomolgus monkey nasal airway was performed. The comparative study was focused on the morphometry and flow dynamics. The study provided high-fidelity qualitative and quantitative linkage between the two species. The study is of significance to effective laboratory data extrapolation between the two species.