Potential impact of family history–based screening guidelines on the detection of early‐onset colorectal cancer. Issue 13 (20th April 2020)

• Record Type: Journal Article
• Authors: Gupta, Samir; Bharti, Balambal; Ahnen, Dennis J.; Buchanan, Daniel D.; Cheng, Iona C.; Cotterchio, Michelle; Figueiredo, Jane C.; Gallinger, Steven J.; Haile, Robert W.; Jenkins, Mark A.; Lindor, Noralane M.; Macrae, Finlay A.; Le Marchand, Loïc; Newcomb, Polly A.; Thibodeau, Stephen N.; Win, Aung Ko; Martinez, Maria Elena
• Is Part Of: Cancer. Volume 126:Issue 13(2020)
• Page Start: 3013
• Page End: 3020
• Publication Date: 2020-04-20
• Subjects: case‐control study -- family history -- guidelines -- sensitivity -- specificity -- young‐onset colorectal cancer; Cancer -- Periodicals; Cancer -- Cytopathology -- Periodicals; 616.99405
• DOI: 10.1002/cncr.32851
• Languages: English
• ISSNs: 0008-543X

Abstract

Abstract : Background: Initiating screening at an earlier age based on cancer family history is one of the primary recommended strategies for the prevention and detection of early‐onset colorectal cancer (EOCRC), but data supporting the effectiveness of this approach are limited. The authors assessed the performance of family history–based guidelines for identifying individuals with EOCRC. Methods: The authors conducted a population‐based, case‐control study of individuals aged 40 to 49 years with (2473 individuals) and without (772 individuals) incident CRC in the Colon Cancer Family Registry from 1998 through 2007. They estimated the sensitivity and specificity of family history–based criteria jointly recommended by the American Cancer Society, the US Multi‐Society Task Force on CRC, and the American College of Radiology in 2008 for early screening, and the age at which each participant could have been recommended screening initiation if these criteria had been applied. Results: Family history–based early screening criteria were met by approximately 25% of cases (614 of 2473 cases) and 10% of controls (74 of 772 controls), with a sensitivity of 25% and a specificity of 90% for identifying EOCRC cases aged 40 to 49 years. Among 614 individuals meeting early screening criteria, 98.4% could have been recommended screening initiation at an age younger than the observed age of diagnosis. Conclusions: Of CRC cases aged 40 to 49 years, 1 in 4 met family history–based early screening criteria, and nearly all cases who met these criteria could have had CRC diagnosed earlier (or possibly even prevented) if earlier screening had been implemented as per family history–based guidelines. Additional strategies are needed to improve the detection and prevention of EOCRC for individuals not meeting family history criteria for early screening. Abstract : Data supporting initiating screening at an earlier age based on family history as a strategy for the detection and prevention of early‐onset colorectal cancer (CRC) are limited. In a population‐based, case‐control study of individuals aged 40 to 49 years, the authors report that 1 in 4 meet guideline criteria for earlier screening, and that nearly all of those who meet these criteria could have had CRC diagnosed earlier (or possibly even prevented) if earlier screening had been implemented as per guidelines.