Factors associated with antibiotic administration delay among preterm infants with late-onset bloodstream infection. (February 2022)

• Record Type: Journal Article
• Authors: Baczynski, M.; Kharrat, A.; Zhu, F.; Ye, X.Y.; Shah, P.S.; Weisz, D.E.; Jain, A.
• Is Part Of: Journal of hospital infection. Volume 120(2022)
• Page Start: 31
• Page End: 35
• Publication Date: 2022-02
• Subjects: Antibiotic administration delay -- Preterm infants -- Late-onset bloodstream infection -- Practice-related factors -- Neonatal intensive care unit -- Quality improvement; Cross infection -- Periodicals; Cross infection -- Prevention -- Periodicals; Nosocomial infections -- Periodicals; Nosocomial infections -- Prevention -- Periodicals; Cross Infection -- Periodicals; Cross Infection -- prevention & control -- Periodicals; Infection Control -- Periodicals; Electronic journals; 614.44
• DOI: 10.1016/j.jhin.2021.09.026
• Languages: English
• ISSNs: 0195-6701

Abstract

Summary: Early antibiotic administration is an important modifiable factor in reducing mortality from late-onset bloodstream infections in preterm infants. In a cohort study including 142 infants with non-coagulase negative staphylococcus bloodstream infection at two tertiary neonatal intensive care units, we identified typical practice-related factors that may be targeted to prevent delays in antibiotic administration. Collection of cerebrospinal fluid or urine sample before administering antibiotics, a longer time taken to site a peripheral intravenous catheter among those without pre-existing access, and a longer time taken to administer fluid boluses were associated with a longer than median time to antibiotic administration.