A case of palatal ancient neurofibroma: Unmasking the histological masquerader. (February 2022) - Krishnan, Reshma Poothakulath
Highlights: Ancient neurofibroma is a rare entity and has not been reported so far in the oral cavity. Histopathological features, such as degenerative changes and nuclear atypia in these ancient neurofibromas may be confused easily with various malignant mesenchymal tumors. Changes in the cellular and nuclear morphology in ancient neurofibroma have been compared to senescence and senescence associated secretory phenotype. The significance of degenerating changes seen in ancient neurofibroma is not well understood and therefore, we have added our interpretations regarding this rare entity. The present case illustrates the hazard of using cellular and nuclear pleomorphism as the single criterion for diagnosing malignant lesions.