Biodegradation of cyclophosphamide and etoposide by white rot fungi and their degradation kinetics. (February 2022)

• Record Type: Journal Article
• Authors: Yadav, Ankush; Rene, Eldon R.; Kanti Mandal, Mrinal; Kumar Dubey, Kashyap
• Is Part Of: Bioresource technology. Volume 346(2022)
• Publication Date: 2022-02
• Subjects: Cytostatic compounds -- Etoposide -- WRFs -- Treatment -- Kinetics; Biomass -- Periodicals; Biomass energy -- Periodicals; Bioremediation -- Periodicals; Agricultural wastes -- Periodicals; Factory and trade waste -- Periodicals; Organic wastes -- Periodicals; Bioénergie -- Périodiques; Déchets agricoles -- Périodiques; Déchets industriels -- Périodiques; Déchets organiques -- Périodiques; Déchets (Combustible) -- Périodiques; 662.88
• DOI: 10.1016/j.biortech.2021.126355
• Languages: English
• ISSNs: 0960-8524

Abstract

Graphical abstract: Highlights: Degradation of antineoplastic compounds by white rot fungi were evaluated. Ganoderma lucidum showed the highest degradation for cyclophosphamide and etoposide. Cyclophosphamide showed highest sorption efficiency with P. chrysosporium. Maximum degradation was achieved for etoposide ( k = 0.54 day −1 ). Abstract: The biodegradation of cyclophosphamide and etoposide by Trametes versicolor (AH05), Ganoderma lucidum (MTCC-1039), and Phanerochaete chrysosporium (MTCC-787) were tested for 3, 6, 9, 12, and 15 days, respectively. G. lucidum achieved the highest degradation efficiency of cyclophosphamide (71.5%) and etoposide (98.4%) after 6 days of treatment. The degradation efficiency of T. versicolor and P. chrysosporium for etoposide was 79.8% and 76.8%, respectively. However, no degradation of cyclophosphamide was achieved with P. chrysosporium, although it showed the highest sorption efficiency for cyclophosphamide (23.7%). Trametes versicolor achieved only 1.4% degradation of cyclophosphamide, that includes both biodegradation and biosorption. The pseudo first-order degradation kinetics explained the degradation of etoposide and cyclophosphamide with t1/2 values of 1.32 and 4.43 days and ' k ' constant of 0.16 and 0.54 day −1, respectively.