Cardiovascular autonomic dysfunction is associated with executive dysfunction and poorer quality of life in progressive supranuclear palsy-Richardson's syndrome. (February 2022)

• Record Type: Journal Article
• Authors: Liu, Peng; Chen, Yueting; Wang, Bo; Wu, Sheng; Zeng, Leilei; Cen, Zhidong; Yang, Dehao; Wang, Haotian; Chen, Xinhui; Wang, Lebo; Ouyang, Zhiyuan; Luo, Wei
• Is Part Of: Journal of clinical neuroscience. Volume 96(2022)
• Page Start: 147
• Page End: 153
• Publication Date: 2022-02
• Subjects: Progressive supranuclear palsy -- Quality of life -- Executive function -- Blood pressure variability -- Ambulatory blood pressure monitoring -- Autonomic dysfunction; Brain -- Surgery -- Periodicals; Neurosciences -- Periodicals; Nervous system -- Surgery -- Periodicals; Brain -- surgery -- Periodicals; Neurosurgical Procedures -- Periodicals; Neurosciences -- Periodicals; Electronic journals; 616.8
• DOI: 10.1016/j.jocn.2021.11.003
• Languages: English
• ISSNs: 0967-5868

Abstract

Highlights: Greater blood pressure variability was associated with poorer quality of life in PSP. Greater blood pressure variability was associated with executive dysfunction in PSP-RS. Abnormal dipping patterns were common in PSP. Abstract: Background: Autonomic dysfunction in progressive supranuclear palsy (PSP) is not uncommon but is easily neglected. Objective: We evaluated blood pressure (BP) profiles in PSP patients and aimed to determine the associations between BP variability and cognition and quality of life. Methods: Consecutive patients diagnosed with PSP were enrolled in this cross-sectional study. All patients underwent 24-hour ambulatory blood pressure monitoring, office blood pressure measurements, and comprehensive clinical assessments. Results: We enrolled 31 PSP patients. Ten (32.3%) patients presented with reverse dipping, 10 (32.3%) presented with reduced dipping, and 11 (35.5%) presented with normal dipping. Additionally, 19 (61.3%) patients had supine hypertension, and no patients had orthostatic hypotension. In the entire PSP cohort, the Movement Disorder Society-Unified Parkinson's Disease Rating Scale part III (MDS-UPDRS III) score, Scales for Outcomes in Parkinson's Disease-Autonomic (SCOPA-AUT) score, and daytime systolic BP (SBP) standard deviation explained 61.5% (adjusted R 2 ) of the variance in Parkinson's Disease Questionnaire-39 (PDQ-39) scores. In the PSP with Richardson's syndrome group, the daytime SBP coefficient of variation and Mini‐Mental State Examination score accounted for 33.9% of the variance in Frontal Assessment Battery scores. The MDS-UPDRS III score, 24-hour SBP coefficient of variation, and SCOPA-AUT score explained 77.6% of the variance in PDQ-39 scores. Conclusions: Greater BP variability was associated with executive dysfunction and poorer quality of life in patients with PSP. A high prevalence of abnormal dipping patterns indicated circadian disruption in patients with PSP.