Family intervention for delirium for patients in the intensive care unit: A systematic meta-analysis. (February 2022)

• Record Type: Journal Article
• Authors: Qin, Mubing; Gao, Yanxia; Guo, Shigong; Lu, Xin; Zhu, Huadong; Li, Yi
• Is Part Of: Journal of clinical neuroscience. Volume 96(2022)
• Page Start: 114
• Page End: 119
• Publication Date: 2022-02
• Subjects: Delirium -- Family intervention -- Family engagement -- ICU; Brain -- Surgery -- Periodicals; Neurosciences -- Periodicals; Nervous system -- Surgery -- Periodicals; Brain -- surgery -- Periodicals; Neurosurgical Procedures -- Periodicals; Neurosciences -- Periodicals; Electronic journals; 616.8
• DOI: 10.1016/j.jocn.2021.11.011
• Languages: English
• ISSNs: 0967-5868

Abstract

Highlights: Delirium is one of the common manifestations of acute brain dysfunction in critically ill patients. We aimed to explore the effect of family intervention on reducing delirium for ICU patients using meta-analysis. It was found that the risk of delirium is 24% lower in the family intervention group, with 95% CI from 0.67 to 0.86. This suggests that family intervention, as an independent approach, is effective in preventing delirium in ICU patients. Abstract: Delirium is one of the common manifestations of acute brain dysfunction in critically ill patients. We aimed to evaluate the effect of family intervention on reducing the delirium incidence in patients hospitalized in the intensive care unit (ICU). We searched electronic databases for randomized clinical trials, cohort, and before-and-after studies up to September 2021 using the MeSH terms ("family" OR "family caregiver") AND ("delirium"). A total of 6 studies including 4199 patients were analyzed. Compared to the control group, the risk of delirium was 24% lower in the family intervention group (OR 0·76 [0·67–0·86], P = 0.20, I 2 = 31%). Pooled data from two trials showed that family intervention was associated with fewer delirium days (SMD: −1.13, 95% CI: −1.91 to −0.34; P = 0.08; I 2 = 67%;). However, there were no significant differences between the two groups in the length of ICU stay, mechanical ventilation duration, and mortality (ICU stay days: MD: −0.62 days; 95% CI: −1.49 to 0.24; P = 0.14; I 2 = 72%; mechanical ventilation days: MD: −0.48 days; 95% CI: −2.10 to 1.13; P = 0.56; I 2 = 0%; mortality: OR: 0.68, 95% CI: 0.22 to 2.09; P = 0.08; I 2 = 67%). Current evidence supports the use of family intervention in reducing the delirium risk and delirium days in hospitalized ICU patients. However, its effects on reducing ICU stay length, ventilation duration, and mortality require further study. Future research should consider identifying the specific family intervention strategies and their duration.