Relationship between the combination of polyunsaturated fatty acids intake and psychological distress during pregnancy: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. (February 2022)

• Record Type: Journal Article
• Authors: Takahashi, I; Obara, T; Aizawa, M; Yonezawa, Y; Ueno, F; Noda, A; Onuma, T; Matsuzaki, F; Murakami, K; Ishikuro, M; Kuriyama, S
• Is Part Of: Prostaglandins, leukotrienes, and essential fatty acids. Volume 177(2022)
• Publication Date: 2022-02
• Subjects: Lipids -- Periodicals; Unsaturated fatty acids -- Periodicals; Prostaglandins -- Periodicals; Leukotrienes -- Periodicals; Fatty Acids, Unsaturated -- Periodicals; Acides gras insaturés -- Périodiques; Prostaglandines -- Périodiques; Leucotriènes -- Périodiques; Lipides -- Périodiques; 612.01577
• DOI: 10.1016/j.plefa.2022.102400
• Languages: English
• ISSNs: 0952-3278

Abstract

Highlights: n-3 and n-6 PUFA intake correlate with psychological distress in pregnancy. A minimum n-6 PUFAs intake may reduce psychological stress in pregnancy. The combination of PUFAs intake should be considered rather than intake ratio. Abstract: No studies have examined the association of the combination of n-3 polyunsaturated fatty acids (PUFAs) and n-6 PUFAs intake with psychological distress during pregnancy. To examine these associations, we divided Japanese pregnant women into 25 groups based on combining quintiles of n-3 PUFAs intake and quintiles of n-6 PUFAs intake. We conducted multivariable logistic regression analyses to assess the risk of psychological distress during pregnancy (Kessler Psychological Distress Scale ≥ 5 or 13). Compared to the third quintile of both n-3 PUFAs and n-6 PUFAs intake, the groups with unbalanced intake, high intake of both, and low intake of both were associated with a higher risk of both Kessler Psychological Distress Scale ≥ 5 and 13 in early and mid-pregnancy. Further research is needed to identify the precise combination of n-3 PUFAs and n-6 PUFAs intake associated with the lowest psychological distress during pregnancy