SUCCOR cone study: conization before radical hysterectomy. Issue 2 (17th January 2022)

• Record Type: Journal Article
• Authors: Chacon, Enrique; Manzour, Nabil; Zanagnolo, Vanna; Querleu, Denis; Núñez-Córdoba, Jorge M; Martin-Calvo, Nerea; Căpîlna, Mihai Emil; Fagotti, Anna; Kucukmetin, Ali; Mom, Constantijne; Chakalova,, Galina; Shamistan, Aliyev; Gil Moreno, Antonio; Malzoni, Mario; Narducci, Fabrice; Arencibia, Octavio; Raspagliesi, Francesco; Toptas, Tayfun; Cibula, David; Kaidarova, Dilyara; Meydanli, Mehmet Mutlu; Tavares, Mariana; Golub, Dmytro; Perrone, Anna Myriam; Poka, Robert; Tsolakidis, Dimitrios; Vujić, Goran; Jedryka, Marcin A; Zusterzeel, Petra L M; Beltman, Jogchum Jan; Goffin, Frederic; Haidopoulos, Dimitrios; Haller, Herman; Jach, Robert; Yezhova, Iryna; Berlev, Igor; Bernardino, Margarida; Bharathan, Rasiah; Lanner, Maximilian; Maenpaa, Minna M; Sukhin, Vladyslav; Feron, Jean-Guillaume; Fruscio, Robert; Kukk, Kersti; Ponce, Jordi; Minguez, Jose Angel; Vázquez-Vicente, Daniel; Castellanos, Teresa; Boria, Felix; Alcazar, Juan Luis; Chiva, Luis;
• Other Names: author non-byline.; Abdalla Nabil author non-byline.; Akgöl Sedat author non-byline.; Aksahin Demirkiran author non-byline.; Aliyev Shamistan author non-byline.; Alonso-Espias Maria author non-byline.; Aluloski Igor author non-byline.; Andrade Claudia author non-byline.; Badzakov Nikola author non-byline.; Barrachina Rosa author non-byline.; Bogani Giorgio author non-byline.; Bonci Eduard-Aexandru author non-byline.; Bonsang-Kitzis Hélène author non-byline.; Brucker Cosima author non-byline.; Cárdenas Laura author non-byline.; Casajuana Andrea author non-byline.; Cavalle Pere author non-byline.; Cea Jorge author non-byline.; Chiofalo Benito author non-byline.; Cordeiro Gloria author non-byline.; Coronado Pluvio author non-byline.; Cuadra Maria author non-byline.; Díez Javier author non-byline.; Costa Teresa Diniz da author non-byline.; Domingo Santiago author non-byline.; Dostalek Lukas author non-byline.; Elif Fuat author non-byline.; Erasun Diego author non-byline.; Fehr Mathias author non-byline.; Fernandez-Gonzalez Sergi author non-byline.; Ferrero Annamaria author non-byline.; Fidalgo Soledad author non-byline.; Fiol Gabriel author non-byline.; Galaal Khadra author non-byline.; García José author non-byline.; Gebauer Gerhard author non-byline.; Ghezzi Fabio author non-byline.; Gilabert Juan author non-byline.; Gomes Nana author non-byline.; Gonçalves Elisabete author non-byline.; Gonzalez Virginia author non-byline.; Grandjean Frederic author non-byline.; Guijarro Miriam author non-byline.; Guyon Frédéric author non-byline.; Haesen Jolien author non-byline.; Hernandez-Cortes Gines author non-byline.; Herrero Sofía author non-byline.; Pete Imre author non-byline.; Kalogiannidis Ioannis author non-byline.; Karaman Erbil author non-byline.; Kavallaris Andreas author non-byline.; Klasa Lukasz author non-byline.; Kotsopoulos Ioannis author non-byline.; Kovachev Stefan author non-byline.; Leht Uppin Arno author non-byline.; Lekuona Arantxa author non-byline.; Luyckx Mathieu author non-byline.; Mallmann Michael author non-byline.; Mancebo Gemma author non-byline.; Mandic Aljosa author non-byline.; Marina Tiermes author non-byline.; Martin Victor author non-byline.; Martín-Salamanca María Belén author non-byline.; Lago Víctor author non-byline.; Martinez Alejandra author non-byline.; Meili Gesine author non-byline.; Mendinhos Gustavo author non-byline.; Mereu Liliana author non-byline.; Mitrovic Milena author non-byline.; Morales Sara author non-byline.; Moratalla Enrique author non-byline.; Gómez-Hidalgo Natalia R author non-byline.; Morillas Bibiana author non-byline.; Myriokefalitaki Eva author non-byline.; PakižImre Maja author non-byline.; Pete Imre author non-byline.; Petousis Stamatios author non-byline.; Pirtea Laurentiu author non-byline.; Povolotskaya Natalia author non-byline.; Prader Sonia author non-byline.; Quesada Alfonso author non-byline.; Redecha Mikuláš author non-byline.; Roldan Fernando author non-byline.; Rolland Philip author non-byline.; Saaron Reeli author non-byline.; Sarac Cosmin-Paul author non-byline.; Scharf Jens-Peter author non-byline.; Smrkolj Špela author non-byline.; Sousa Rita author non-byline.; Stepanyan Artem author non-byline.; Študent Vladimír author non-byline.; Tauste Carmen author non-byline.; Trum Hans author non-byline.; Turan Taner author non-byline.; Undurraga Manuela author non-byline.; Vázquez Alicia author non-byline.; Vergote Ignace author non-byline.; Vorgias George author non-byline.; Zapardiel Ignacio author non-byline.;
• Is Part Of: International journal of gynecological cancer. Volume 32:Issue 2(2022)
• Page Start: 117
• Page End: 124
• Publication Date: 2022-01-17
• Subjects: cervical cancer -- surgery -- hysterectomy -- laparoscopes -- laparotomy; Generative organs, Female -- Cancer -- Periodicals; 616.99465
• DOI: 10.1136/ijgc-2021-002544
• Languages: English
• ISSNs: 1048-891X

Abstract

Abstract : Objective: To evaluate disease-free survival of cervical conization prior to radical hysterectomy in patients with stage IB1 cervical cancer (International Federation of Gynecology and Obstetrics (FIGO) 2009). Methods: A multicenter retrospective observational cohort study was conducted including patients from the Surgery in Cervical Cancer Comparing Different Surgical Aproaches in Stage IB1 Cervical Cancer (SUCCOR) database with FIGO 2009 IB1 cervical carcinoma treated with radical hysterectomy between January 1, 2013, and December 31, 2014. We used propensity score matching to minimize the potential allocation biases arising from the retrospective design. Patients who underwent conization but were similar for other measured characteristics were matched 1:1 to patients from the non-cone group using a caliper width ≤0.2 standard deviations of the logit odds of the estimated propensity score. Results: We obtained a weighted cohort of 374 patients (187 patients with prior conization and 187 non-conization patients). We found a 65% reduction in the risk of relapse for patients who had cervical conization prior to radical hysterectomy (hazard ratio (HR) 0.35, 95% confidence interval (CI) 0.16 to 0.75, p=0.007) and a 75% reduction in the risk of death for the same sample (HR 0.25, 95% CI 0.07 to 0.90, p=0.033). In addition, patients who underwent minimally invasive surgery without prior conization had a 5.63 times higher chance of relapse compared with those who had an open approach and previous conization (HR 5.63, 95% CI 1.64 to 19.3, p=0.006). Patients who underwent minimally invasive surgery with prior conization and those who underwent open surgery without prior conization showed no differences in relapse rates compared with those who underwent open surgery with prior cone biopsy (reference) (HR 1.94, 95% CI 0.49 to 7.76, p=0.349 and HR 2.94, 95% CI 0.80 to 10.86, p=0.106 respectively). Conclusions: In this retrospective study, patients undergoing cervical conization before radical hysterectomy had a significantly lower risk of relapse and death.