The skin redoxome. (26th November 2021)

• Record Type: Journal Article
• Authors: Schalka, S.; Silva, M.S.; Lopes, L.F.; de Freitas, L.M.; Baptista, M.S.
• Is Part Of: Journal of the European Academy of Dermatology and Venereology. Volume 36:Number 2(2022)
• Page Start: 181
• Page End: 195
• Publication Date: 2021-11-26
• Subjects: Dermatology -- Periodicals; Sexually transmitted diseases -- Periodicals; 616.5
• DOI: 10.1111/jdv.17780
• Languages: English
• ISSNs: 0926-9959

Abstract

Abstract: Redoxome is the network of redox reactions and redox active species (ReAS) that affect the homeostasis of cells and tissues. Due to the intense and constant interaction with external agents, the human skin has a robust redox signalling framework with specific pathways and magnitudes. The establishment of the skin redoxome concept is key to expanding knowledge of skin disorders and establishing better strategies for their prevention and treatment. This review starts with its definition and progress to propose how the master redox regulators are maintained and activated in the different conditions experienced by the skin and how the lack of redox regulation is involved in the accumulation of several oxidation end products that are correlated with various skin disorders.