Role of Inhibitor SMADs in Stage 3 Grade B periodontitis before and after periodontal treatment. (28th September 2021)

• Record Type: Journal Article
• Authors: Çelen, Selman; Öngöz Dede, Figen; Avşar, Candeğer
• Is Part Of: Journal of periodontal research. Volume 57:Number 1(2022)
• Page Start: 41
• Page End: 51
• Publication Date: 2021-09-28
• Subjects: gingival crevicular fluid -- non‐surgical periodontal treatment -- periodontitis -- saliva -- Smad6 -- Smad7 -- TGF‐β; Periodontics -- Periodicals; 617.632
• DOI: 10.1111/jre.12935
• Languages: English
• ISSNs: 0022-3484

Abstract

Abstract: Objective: This study aimed to examine the levels of transforming growth factor‐beta (TGF‐β) and inhibitory‐Smads (I‐Smads) in saliva and gingival crevicular fluid (GCF) in patients with Stage 3 Grade B periodontitis before and after non‐surgical periodontal treatment. Background: Recently, it has been stated that Smads play an active role in all conditions where TGF‐β is involved, including periodontal inflammation. Methods: Twenty healthy participants (control) and 20 patients with Stage 3, Grade B periodontitis were recruited. GCF and saliva samples and clinical periodontal recordings were investigated at the baseline and 1 month after treatment. TGF‐β and I‐Smads (Smads 6 and 7) were determined by ELISA. Results: Salivary Smad6 and Smad7 levels were significantly lower in the periodontitis group than healthy controls (p < .05), while there was no difference in salivary TGF‐β levels between groups at baseline (p > .05). The total amounts and concentrations of GCF TGF‐β, Smad6, and Smad7 were significantly lower in the periodontitis group than healthy controls at baseline (p < .05), and then decreased in concentration levels with treatment (p < .001). Positive correlations were found between total amounts and concentrations of GCF TGF‐β, Smad6, and Smad7 (p < .05). Conclusion: Our findings revealed that Smad6 and Smad7 in GCF and saliva decreased in periodontitis and then increased after periodontal treatment. Our study suggests that I‐Smads act in parallel with TGF‐β in periodontal inflammation and may have a role in the development of periodontitis.