A Guideline for the Synthesis of Amino‐Acid‐Functionalized Monomers and Their Polymerizations. Issue 2 (25th November 2021)

• Record Type: Journal Article
• Authors: Leiske, Meike N.; Kempe, Kristian
• Is Part Of: Macromolecular rapid communications. Volume 43:Issue 2(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-11-25
• Subjects: amino acids -- polypeptides -- polypeptoids -- reversible deactivation radical polymerization -- ring‐opening polymerization; Macromolecules -- Periodicals; Polymers -- Periodicals; Chemistry -- Periodicals; 547.705
• DOI: 10.1002/marc.202100615
• Languages: English
• ISSNs: 1022-1336

Abstract

Abstract: Amino acids have emerged as a sustainable source for the design of functional polymers. Besides their wide availability, especially their high degree of biocompatibility makes them appealing for a broad range of applications in the biomedical research field. In addition to these favorable characteristics, the versatility of reactive functional groups in amino acids (i.e., carboxylic acids, amines, thiols, and hydroxyl groups) makes them suitable starting materials for various polymerization approaches, which include step‐ and chain‐growth reactions. This review aims to provide an overview of strategies to incorporate amino acids into polymers. To this end, it focuses on the preparation of polymerizable monomers from amino acids, which yield main chain or side chain‐functionalized polymers. Furthermore, postpolymerization modification approaches for polymer side chain functionalization are discussed. Amino acids are presented as a versatile platform for the development of polymers with tailored properties. Abstract : Amino acids are sustainable materials, which can serve as starting materials for the design of a large variety of polymerizable monomers. Applied polymerization techniques, which go far beyond traditional peptide synthesis, include polycondensation, ring‐opening polymerization, ring‐opening metathesis polymerization, and reversible deactivation radical polymerization approaches. This versatility makes amino acids the ideal starting material for the design of biocompatible and functional polymer materials.