Frequency of signs of chronic gastrointestinal disease in dogs after an episode of acute hemorrhagic diarrhea. (10th December 2021)

• Record Type: Journal Article
• Authors: Skotnitzki, Elisabeth; Suchodolski, Jan S.; Busch, Kathrin; Werner, Melanie; Zablotski, Yury; Ballhausen, Bianca D.; Neuerer, Felix; Unterer, Stefan
• Is Part Of: Journal of veterinary internal medicine. Volume 36:Number 1(2022)
• Page Start: 59
• Page End: 65
• Publication Date: 2021-12-10
• Subjects: AHDS -- canine -- enteropathy -- HGE -- IBD -- intestinal; Veterinary medicine -- Periodicals; 636.0896
• DOI: 10.1111/jvim.16312
• Languages: English
• ISSNs: 0891-6640

Abstract

Abstract: Background: Acute enteropathy is a trigger of chronic gastrointestinal (GI) disease in humans. Objective: To report the prevalence of and explore possible risk factors for signs of chronic GI disease in dogs after an episode of acute hemorrhagic diarrhea (AHD). Animals: One hundred and fifty‐one dogs, 80 dogs with a historical diagnosis of AHD, 71 control dogs with no history of AHD. Methods: In this retrospective longitudinal study, data were collected from dogs with a historical diagnosis of AHD and healthy controls matched by breed, age and sex, aged between 1 year and 15 years of age, for which a follow‐up of at least 12 months after enrolment was available. Dog owners responded to a questionnaire to determine the history of signs of chronic GI disease. Results: There was a higher prevalence of signs of chronic GI disease in the dogs with a previous episode of AHD compared to control dogs (AHD 28%; controls 13%; P = .03; odds ratio = 2.57; confidence interval [CI] 95% 1.12‐6.31) over a similar observation time (median 4 years; range, 1‐12 years). Conclusions and Clinical Importance: Severe intestinal mucosal damage and associated barrier dysfunction might trigger chronic GI disease later in life.