Glucocorticoid pharmacogenetics in pediatric idiopathic nephrotic syndrome. (September 2015)

• Record Type: Journal Article
• Authors: Cuzzoni, Eva; De Iudicibus, Sara; Franca, Raffaella; Stocco, Gabriele; Lucafò, Marianna; Pelin, Marco; Favretto, Diego; Pasini, Andrea; Montini, Giovanni; Decorti, Giuliana
• Is Part Of: Pharmacogenomics. Volume 16:Number 14(2015)
• Page Start: 1631
• Page End: 1648
• Publication Date: 2015-09
• Subjects: glucocorticoids -- glucocorticoid receptor -- glucocorticoid receptor heterocomplex -- idiopathic nephrotic syndrome -- inflammatory mediators -- P-gp -- polymorphisms; Pharmacogenomics -- Periodicals; 615.1
• DOI: 10.2217/pgs.15.101
• Languages: English
• ISSNs: 1462-2416

Abstract

Idiopathic nephrotic syndrome represents the most common type of primary glomerular disease in children: glucocorticoids (GCs) are the first-line therapy, even if considerable interindividual differences in thepir efficacy and side effects have been reported. Immunosuppressive and anti-inflammatory effects of these drugs are mainly due to the GC-mediated transcription regulation of pro- and anti-inflammatory genes. This mechanism of action is the result of a complex multistep pathway that involves the glucocorticoid receptor and several other proteins, encoded by polymorphic genes. Aim of this review is to highlight the current knowledge on genetic variants that could affect GC response, particularly focusing on children with idiopathic nephrotic syndrome.