A candidate gene approach of the calcineurin pathway to identify variants associated with clinical outcomes in renal transplantation. (March 2016)

• Record Type: Journal Article
• Authors: Pouché, Lucie; Koitka, Matthias; Stojanova, Jana; Woillard, Jean-Baptiste; Monchaud, Caroline; Villeneuve, Claire; Essig, Marie; Abraham, Julie; Le Meur, Yannick; Rerolle, Jean-Phillippe; Kamar, Nassim; Rostaing, Lionel; Merville, Pierre; Gandia, Peggy; Bouchet, Stephane; Petersen, Britt-Sabina; Marquet, Pierre; Picard, Nicolas
• Is Part Of: Pharmacogenomics. Volume 17:Number 4(2016)
• Page Start: 375
• Page End: 391
• Publication Date: 2016-03
• Subjects: acute rejection -- calcineurin -- ciclosporin -- genetic polymorphism -- kidney transplantation -- opportunistic infections -- pharmacogenetics -- tacrolimus; Pharmacogenomics -- Periodicals; 615.1
• DOI: 10.2217/pgs.15.181
• Languages: English
• ISSNs: 1462-2416

Abstract

Aim: To investigate the potential influence of variants in genes involved in the calcineurin pathway on the efficacy and toxicity of calcineurin inhibitors in renal transplantation.Materials & methods: Twenty-three polymorphisms in thirteen genes were tested in 381 renal transplant recipients receiving ciclosporin (n = 221) or tacrolimus (n = 160) and mycophenolate mofetil. Data were collected prospectively over the first year post-transplantation.Results: Multivariate survival analyses revealed no genetic associations with biopsy proven acute graft rejection and serious infections. Donor–recipient Cytomegalovirus mismatch was the only variable associated with serious infection.Conclusion: This large exploratory study casts doubts on the potential interest of genetic biomarkers related to CNI pharmacodynamics but associations with other phenotypes in transplantation deserve further studies.