EPR Characterisation of Phthalocyanine Radical Anions in Near‐Infrared Photocleavage of the Hydrophilic Axial Ligand of a Photoimmunotherapeutic Reagent, IR700. Issue 1 (13th December 2021)

• Record Type: Journal Article
• Authors: Inanami, Osamu; Hiraoka, Wakako; Goto, Yuto; Takakura, Hideo; Ogawa, Mikako
• Is Part Of: ChemPhotoChem. Volume 6:Issue 1(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-12-13
• Subjects: Photochemistry -- Periodicals; Periodicals; Electronic journals; 541.35
• DOI: 10.1002/cptc.202100277
• Languages: English
• ISSNs: 2367-0932

Abstract

Abstract: The front cover artwork is provided by Osamu Inanami, Mikako Ogawa and co‐workers at Hokkaido University and Meiji University (Japan). The image shows the formation mechanism of photoinduced cytotoxic aggregation through two‐step cleavage reactions of the hydrophilic axial ligands of IR700 in photoimmunotherapy. Read the full text of the Article at 10.1002/cptc.202100172 . Abstract : "Photoimmunotherapy (PIT) is a novel cancer therapy that utilises tumour‐specific monoclonal antibodies coupled with a silicon phthalocyanine derivative with biaxial ligands (IR700). Near‐infrared (NIR)‐induced cleavage of these axial ligands was proposed to induce the aggregation of IR700 on the cell membrane, resulting in cell death. Herein, using electron paramagnetic resonance (EPR) spectroscopy, two types of IR700 anion radicals with different anisotropies were identified as the precursors of the two‐step NIR‐induced cleavage reaction of the axial ligand of IR700…" This and more about the story behind the front cover can be found in the Article at 10.1002/cptc.202100172 .