HIF3A association with adiposity: the story begins before birth. (September 2015)

• Record Type: Journal Article
• Authors: Pan, Hong; Lin, Xinyi; Wu, Yonghui; Chen, Li; Teh, Ai Ling; Soh, Shu E; Lee, Yung Seng; Tint, Mya Thway; MacIsaac, Julia L; Morin, Alexander M; Tan, Kok Hian; Yap, Fabian; Saw, Seang Mei; Kobor, Michael S; Meaney, Michael J; Godfrey, Keith M; Chong, Yap-Seng; Gluckman, Peter D; Karnani, Neerja; Holbrook, Joanna D
• Is Part Of: Epigenomics. Volume 7:Number 6(2015)
• Page Start: 937
• Page End: 950
• Publication Date: 2015-09
• Subjects: birth weight -- DNA methylation -- embryonic and fetal development -- epigenomics -- HIF3A protein -- human -- obesity; Epigenesis -- Periodicals; Genomics -- Periodicals; Chromatin -- Periodicals; DNA -- Periodicals; 572.87
• DOI: 10.2217/epi.15.45
• Languages: English
• ISSNs: 1750-1911

Abstract

Aim: Determine if the association of HIF3A DNA methylation with weight and adiposity is detectable early in life.Material & methods: We determined HIF3A genotype and DNA methylation patterns (on hybridization arrays) in DNA extracted from umbilical cords of 991 infants. Methylation levels at three CpGs in the HIF3A first intron were related to neonatal and infant anthropometry and to genotype at nearby polymorphic sites.Results & conclusion: Higher methylation levels at three previously described HIF3A CpGs were associated with greater infant weight and adiposity. The effect sizes were slightly smaller than those reported for adult BMI. There was also an interaction within cis -genotype. The association between higher DNA methylation at HIF3A and increased adiposity is present in neonates. In this study, no particular prenatal factor strongly influenced HIF3A hypermethylation. Our data nonetheless suggest shared prenatal influences on HIF3A methylation and adiposity.