Epigenetic regulation by histone demethylases in hypoxia. (August 2015)

• Record Type: Journal Article
• Authors: Hancock, Rebecca L; Dunne, Kate; Walport, Louise J; Flashman, Emily; Kawamura, Akane
• Is Part Of: Epigenomics. Volume 7:Number 5(2015)
• Page Start: 791
• Page End: 811
• Publication Date: 2015-08
• Subjects: 2-oxoglutarate dependent oxygenases -- cancer -- cardiovascular diseases -- development -- epigenetic regulation -- H3 -- HIF -- histone 3 -- histone demethylases -- hypoxia -- KDMs -- oxygen kinetics -- oxygen sensors; Epigenesis -- Periodicals; Genomics -- Periodicals; Chromatin -- Periodicals; DNA -- Periodicals; 572.87
• DOI: 10.2217/epi.15.24
• Languages: English
• ISSNs: 1750-1911

Abstract

The response to hypoxia is primarily mediated by the hypoxia-inducible transcription factor (HIF). Levels of HIF are regulated by the oxygen-sensing HIF hydroxylases, members of the 2-oxoglutarate (2OG) dependent oxygenase family. JmjC-domain containing histone lysine demethylases (JmjC-KDMs), also members of the 2OG oxygenase family, are key epigenetic regulators that modulate the methylation levels of histone tails. Kinetic studies of the JmjC-KDMs indicate they could also act in an oxygen-sensitive manner. This may have important implications for epigenetic regulation in hypoxia. In this review we examine evidence that the levels and activity of JmjC-KDMs are sensitive to oxygen availability, and consider how this may influence their roles in early development and hypoxic disease states including cancer and cardiovascular disease.