Prognostic and predictive value of epigenetic biomarkers and clinical factors in upper tract urothelial carcinoma. (August 2015)

• Record Type: Journal Article
• Authors: Xiong, Gengyan; Liu, Jin; Tang, Qi; Fan, Yu; Fang, Dong; Yang, Kaiwei; Xie, Feng; Zhang, Min; Zhang, Lei; Liu, Libo; Zhang, Cuijian; Yao, Lin; Yang, Li; Ci, Weimin; Zhao, Wei; Gong, Yanqing; He, Qun; Gong, Kan; He, Zhisong; Wang, Gang; Li, Xuesong; Guo, Yinglu; Zhou, Liqun
• Is Part Of: Epigenomics. Volume 7:Number 5(2015)
• Page Start: 733
• Page End: 744
• Publication Date: 2015-08
• Subjects: epigenetic biomarkers -- nomogram -- oncological outcomes -- predictive model -- upper tract urothelial carcinoma; Epigenesis -- Periodicals; Genomics -- Periodicals; Chromatin -- Periodicals; DNA -- Periodicals; 572.87
• DOI: 10.2217/epi.15.34
• Languages: English
• ISSNs: 1750-1911

Abstract

Aim: We conducted this study to identify gene promoter methylation status and clinical predictors for upper tract urothelial carcinoma (UTUC) patients.Materials & methods: Using methylation-sensitive PCR, we examined ten genes promoter methylation status in 687 UTUC patients.Results: A methylated promoter of three genes to predict higher tumor stage (T3 and T4), five genes to predict higher tumor grade (G3) and one gene to predict pN+ were certified in this study. Nine factors were significantly associated with poor cancer-specific survival. Six factors were considered as predictors to develop bladder recurrence after surgery.Conclusion: Methylation occurs commonly in UTUCs, may affect carcinogenic mechanisms, and is a well predictive factor for cancer-specific survival and bladder recurrence in UTUCs.