Covid‐19 sequelae in working age patients: A systematic review. Issue 3 (22nd October 2021)

• Record Type: Journal Article
• Authors: d'Ettorre, Gabriele; Gentilini Cacciola, Elio; Santinelli, Letizia; De Girolamo, Gabriella; Spagnolello, Ornella; Russo, Alessandro; Tarsitani, Lorenzo; Ciccozzi, Massimo; Mastroianni, Claudio M.; d'Ettorre, Gabriella; Ceccarelli, Giancarlo
• Other Names: Luo Guangxiang (George) guestEditor.; Ly Hinh guestEditor.; Gao Shou‐Jiang guestEditor.
• Is Part Of: Journal of medical virology. Volume 94:Issue 3(2022)
• Page Start: 858
• Page End: 868
• Publication Date: 2021-10-22
• Subjects: Covid‐19 -- neuropsychological symptoms -- pneumological symptoms -- post‐Covid syndrome -- SARS‐CoV -- sequelae -- systematic review -- working age patients; Virology -- Periodicals; 616
• DOI: 10.1002/jmv.27399
• Languages: English
• ISSNs: 0146-6615

Abstract

Abstract: Despite the SARS‐CoV‐2 pandemic not yet being under control, post‐Covid‐19 syndrome is already a challenging topic: long‐term multiorgan sequelae, although increasingly described, have not yet been systematized. As post‐Covid‐19 syndrome can significantly impact both the working capacity and the relationship life of surviving patients, we performed a systematic review of the evidence published over the last year and currently available in medical literature search databases (MEDLINE/Pubmed) and searching clinical trial registries, to evaluate the available evidence among workers. From 31 publications that initially matched inclusion criteria, 13 studies have been considered suitable for relevance and age of subjects. A wide range of patients (16%–87%) have post‐Covid syndrome; pneumological and neuropsychological symptoms were the most common disorders reported. The most frequent organic sequel found in post‐Covid patients was pulmonary fibrosis. The number of symptoms during acute SARS‐CoV‐2 infection, severity of the disease, and high serum levels of d ‐dimer were related to high risk of post‐Covid syndrome. In conclusion, post‐Covid‐19 syndrome can significantly impact the health conditions of surviving patients. Rehabilitation and follow‐up in multidisciplinary rehabilitation programs should be considered for working‐age patients.