Quercetin and its derivates as antiviral potentials: A comprehensive review. (28th October 2021)

• Record Type: Journal Article
• Authors: Di Petrillo, Amalia; Orrù, Germano; Fais, Antonella; Fantini, Massimo C.
• Is Part Of: Phytotherapy research. Volume 36:Number 1(2022)
• Page Start: 266
• Page End: 278
• Publication Date: 2021-10-28
• Subjects: antiviral -- coronavirus -- HCV -- HIV -- influenza virus H1N1 -- quercetin; Materia medica, Vegetable -- Periodicals; Botany, Medical -- Periodicals; Medicinal plants -- Periodicals; Plant Extracts -- therapeutic use -- Periodicals; Plants, Medicinal -- Periodicals; 581.634
• DOI: 10.1002/ptr.7309
• Languages: English
• ISSNs: 0951-418X

Abstract

Abstract : Quercetin, widely distributed in fruits and vegetables, is a flavonoid known for its antioxidant, antiviral, antimicrobial, and antiinflammatory properties. Several studies highlight the potential use of quercetin as an antiviral, due to its ability to inhibit the initial stages of virus infection, to be able to interact with proteases important for viral replication, and to reduce inflammation caused by infection. Quercetin could also be useful in combination with other drugs to potentially enhance the effects or synergistically interact with them, in order to reduce their side effects and related toxicity. Since there is no comprehensive compilation about antiviral activities of quercetin and derivates, the aim of this review is providing a summary of their antiviral activities on a set of human viral infections along with mechanisms of action. Thus, the following family of viruses are examined: Flaviviridae, Herpesviridae, Orthomyxoviridae, Coronaviridae, Hepadnaviridae, Retroviridae, Picornaviridae, Pneumoviridae, and Filoviridae.