Old dog, new tricks: Polydatin as a multitarget agent for current diseases. (22nd December 2021)

• Record Type: Journal Article
• Authors: Ye, Penghui; Wu, Hefei; Jiang, Yinxiao; Xiao, Xiaolin; Song, Dan; Xu, Nuo; Ma, Xiao; Zeng, Jinhao; Guo, Yaoguang
• Is Part Of: Phytotherapy research. Volume 36:Number 1(2022)
• Page Start: 214
• Page End: 230
• Publication Date: 2021-12-22
• Subjects: antiinflammatory effects -- antioxidative effects -- lipid regulation -- maintenance of mitochondrial function -- polydatin -- regulation of autophagy and apoptosis; Materia medica, Vegetable -- Periodicals; Botany, Medical -- Periodicals; Medicinal plants -- Periodicals; Plant Extracts -- therapeutic use -- Periodicals; Plants, Medicinal -- Periodicals; 581.634
• DOI: 10.1002/ptr.7306
• Languages: English
• ISSNs: 0951-418X

Abstract

Abstract: Polydatin (PD) is a natural single‐crystal product that is primarily extracted from the traditional plant Polygonum cuspidatum Sieb. et Zucc . Early research showed that PD exhibited a variety of biological activities. PD has attracted increasing research interest since 2014, but no review comprehensively summarized the new findings. A great gap between its biological activities and drug development remains. It is necessary to summarize new findings on the pharmacological effects of PD on current diseases. We propose that PD will most likely be used in cardiac and cerebral ischaemia/reperfusion‐related diseases and atherosclerosis in the future. The present work classified these new findings according to diseases and summarized the main effects of PD via specific mechanisms of action. In summary, we found that PD played a therapeutic role in a variety of diseases, primarily via five mechanisms: antioxidative effects, antiinflammatory effects, regulation of autophagy and apoptosis, maintenance of mitochondrial function, and lipid regulation.