Correlating intraepithelial papillary capillary loops of vocal cord leukoplakia with histopathology. (2nd January 2022)

• Record Type: Journal Article
• Authors: Fang, Yi; Yang, Yue; Chen, Min; Chen, Jian; He, Peijie; Cheng, Lei; Wu, Haitao
• Is Part Of: Acta oto-laryngologica. Volume 142:Number 1(2022)
• Page Start: 106
• Page End: 111
• Publication Date: 2022-01-02
• Subjects: Vocal cord leukoplakia -- narrow-band imaging -- intraepithelial papillary capillary loop: pathology; Otolaryngology -- Periodicals; Ear -- Diseases -- Periodicals; Throat -- Diseases -- Periodicals; Otolaryngology -- Electronic Resources; Otorhinolaryngologic Diseases; 617.8
• DOI: 10.1080/00016489.2021.2019828
• Languages: English
• ISSNs: 0001-6489

Abstract

Abstract: Background: The pathology of vocal fold leukoplakia (VFL) was hard to predict before surgery. Objectives: To investigate the correlation of intraepithelial papillary capillary loops (IPCLs) with the malignant transformation in VFL. Materials and Methods: The IPCLs in 90 patients were classified according to 2019 Ni classification. Type I–III represented to non- to moderate dysplasia in pathology being viewed as 'benign leukoplasia', type IV–VI represented to severe dysplasia/cancer in situ, cancerization being viewed as 'malignant leukoplasia'. The corresponding relationship of IPCLs with pathology was calculated. Results: Forty-one cases were classified as type I–III, the consistency of type I–III with pathology was 61.0%, with 100.0% of type I, 47.1% of type II and 30.0% of type III. 49 cases were classified as type IV–VI, all were 'malignant leukoplasia', the consistency of type IV–VI and pathology was 100.0%. The accuracy of type I–III, IV–VI to predict pathology were 61.0, 100.0%. The sensitivity, specificity, accuracy, positive predictive value, negative predictive value of Ni classification corresponding to 'benign/malignant leukoplasia' was 75.8, 100.0, 82.2, 100.0, 60.0%, respectively. Conclusions and Significance: IPCLs of type IV–VI in vocal cord leukoplasia had a close correlation with pathology. The degree of dysplasia was underestimated in type II and type III.