Lipopolysaccharides derived from gram-negative bacterial pool of human gut microbiota promote inflammation and obesity development. (2nd January 2022)

• Record Type: Journal Article
• Authors: Du, Liyu; Lei, Xi; Wang, Jie; Wang, Li; Zhong, Qingping; Fang, Xiang; Li, Pan; Du, Bing; Wang, Yutao; Liao, Zhenlin
• Is Part Of: International reviews of immunology. Volume 41:Number 1(2022)
• Page Start: 45
• Page End: 56
• Publication Date: 2022-01-02
• Subjects: Endotoxin -- lipopolysaccharides -- high-fat diet -- inflammation -- obesity -- gut permeability; Immunology -- Periodicals; Autoimmune diseases -- Periodicals; 616.079
• DOI: 10.1080/08830185.2021.1996573
• Languages: English
• ISSNs: 0883-0185

Abstract

Abstract: Lipopolysaccharide (LPS) is the major component of the outer membrane of Gram-negative bacteria. It is found from intestinal microbes in the circulatory system and considered a trigger factor for low-grade inflammation in obesity. High-fat diet intake and its related obesity can cause gut microbiota disorder, leading to increased gut permeability, paracellular absorption and transcellular transport of endogenous endotoxin in the cardiovascular system. High-fat diet intake can also increase plasma LPS levels, and causing chronic or "low-grade" inflammation. In this review article, we summarize the recent research advancements on the mechanism of low-grade inflammation and its related obesity. We also propose several approaches that can be used to reduce endogenous endotoxin absorption. Supplemental data for this article is available online at https://doi.org/10.1080/08830185.2021.1996573 . GRAPHICAL ABSTRACT: