Triterpenoids and lignans from Schisandra chinensis and their inhibition activities of Cdc25A/B phosphatases. Issue 3 (1st February 2022)

• Record Type: Journal Article
• Authors: Zhao, Qian-Qian; Wei, Wen-Jun; Li, Ya; Gao, Kun
• Is Part Of: Natural product research. Volume 36:Issue 3(2022)
• Page Start: 754
• Page End: 759
• Publication Date: 2022-02-01
• Subjects: Schisandra chinensis -- triterpenoid -- lignan -- Cdc25A/B phosphatases; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2020.1802268
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Three new highly modified lanostane triterpenoids schisanchinlactone A-C (1 –3 ), together with six known compounds (4 –9 ) were isolated from the stems and leaves of Schisandra chinensis . Their structures were established by extensive spectroscopic analyses. Compounds 7 and 8 showed significant inhibition of Cdc25A phosphatase with inhibitory rates of 85.5% and 98.1%, respectively, at the concentration of 100 μM. Graphical Abstract: