Foxglove poisoning: diagnostic and therapeutic differences with medicinal digitalis glycosides overdose. Issue 1 (2nd January 2022)

• Record Type: Journal Article
• Authors: Maes, Koen R.; Depuydt, Pieter; Vermassen, Joris; De Paepe, Peter; Buylaert, Walter; Lyphout, Cathelijne
• Is Part Of: Acta clinica belgica. Volume 77:Issue 1(2022)
• Page Start: 101
• Page End: 107
• Publication Date: 2022-01-02
• Subjects: Digitalis purpurea poisoning -- fab fragments -- digitoxicity -- foxglove; Clinical medicine -- Periodicals; Diagnosis, Laboratory -- Periodicals; 616.005
• DOI: 10.1080/17843286.2020.1773652
• Languages: English
• ISSNs: 1784-3286

Abstract

ABSTRACT: We report a case of a 19-year-old woman who ingested Digitalis purpurea leaves as a suicide attempt. She developed gastro-intestinal symptoms, loss of colour vision, cardiac conduction disturbances as well as an elevated serum potassium. Treatment was initiated in analogy to medicinal digoxin poisoning by means of digoxin-specific Fab-fragments with a good effect. However during the further course we faced difficulties of prolonged intestinal absorption and inability to estimate the ingested dose or half-life of the vegetal cardiac glycoside compounds. To prevent further absorption and interrupt enterohepatic recycling, multi-dose activated charcoal was administered. Because of a relapse of cardiac conduction disturbances and hyperkalemia, two supplementary doses of Fab-fragments were given, up to a total dose of nineteen vials (one vial containing 40 mg). The important diagnostic and therapeutic differences of vegetal digitalis intoxication as compared to medicinal intoxication and the applicability of existing guidelines on medicinal digitalis intoxication in the light of these differences will be discussed here.