H2O2-mediated room temperature synthesis of 2-arylacetophenones from arylhydrazines and vinyl azides in water. Issue 3 (22nd December 2021)

• Record Type: Journal Article
• Authors: Luo, Mengqiang; Zhang, Yaohong; Fang, Ping; Li, Yan; Qi, Chenze; Li, Yong; Shen, Runpu; Cheng, Kai; Wang, Hai
• Is Part Of: Organic & biomolecular chemistry. Volume 20:Issue 3(2021)
• Page Start: 630
• Page End: 635
• Publication Date: 2021-12-22
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d1ob02023d
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : An environmentally benign, cost-efficient and practical methodology for the room temperature synthesis of 2-arylacetophenones in water has been discovered. Abstract : An environmentally benign, cost-efficient and practical methodology for the room temperature synthesis of 2-arylacetophenones in water has been discovered. The facile and efficient transformation involves the oxidative radical addition of arylhydrazines with α-aryl vinyl azides in the presence of H2 O2 (as a radical initiator) and PEG-800 (as a phase-transfer catalyst). From the viewpoint of green chemistry and organic synthesis, the present protocol is of great significance because of using cheap, non-toxic and readily available starting materials and reagents as well as amenability to gram-scale synthesis, which provides an attractive strategy to access 2-arylacetophenones.