Associations Between Vancomycin Exposure and Acute Kidney Injury Within the Recommended Area Under the Curve Therapeutic Exposure Range Among Patients With Methicillin-Resistant Staphylococcus aureus Bloodstream Infections. (22nd January 2022)

• Record Type: Journal Article
• Authors: Lodise, Thomas P; Scheetz, Marc; Carreno, Joseph J; Chambers, Henry; Fowler, Vance; Holland, Thomas L
• Is Part Of: Open forum infectious diseases. Volume 9:Number 2(2022)
• Publication Date: 2022-01-22
• Subjects: MRSA -- outcomes -- pharmacokinetics -- vancomycin; Communicable diseases -- Periodicals; Medical microbiology -- Periodicals; Infection -- Periodicals; 616.9
• DOI: 10.1093/ofid/ofab651
• Languages: English
• ISSNs: 2328-8957

Abstract

Abstract: Among patients with methicillin-resistant Staphylococcus aureus bacteremia, vancomycin-associated acute kidney injury increased as a function of the day 2 area under the curve (AUC), even for daily AUCs within the recommended therapeutic range (400–600). Further data are needed to determine if daily AUCs <400 can be maintained without compromising efficacy.