Network analytics for drug repurposing in COVID-19. Issue 1 (7th December 2021)

• Record Type: Journal Article
• Authors: Siminea, Nicoleta; Popescu, Victor; Sanchez Martin, Jose Angel; Florea, Daniela; Gavril, Georgiana; Gheorghe, Ana-Maria; Iţcuş, Corina; Kanhaiya, Krishna; Pacioglu, Octavian; Popa, Laura lona; Trandafir, Romica; Tusa, Maria Iris; Sidoroff, Manuela; Păun, Mihaela; Czeizler, Eugen; Păun, Andrei; Petre, Ion
• Is Part Of: Briefings in bioinformatics. Volume 23:Issue 1(2022)
• Publication Date: 2021-12-07
• Subjects: COVID-19 -- drug repurposing -- network biology -- network controllability -- host factors; Genetics -- Data processing -- Periodicals; Molecular biology -- Data processing -- Periodicals; Genomes -- Data processing -- Periodicals; 572.80285
• DOI: 10.1093/bib/bbab490
• Languages: English
• ISSNs: 1467-5463

Abstract

Abstract: To better understand the potential of drug repurposing in COVID-19, we analyzed control strategies over essential host factors for SARS-CoV-2 infection. We constructed comprehensive directed protein–protein interaction (PPI) networks integrating the top-ranked host factors, the drug target proteins and directed PPI data. We analyzed the networks to identify drug targets and combinations thereof that offer efficient control over the host factors. We validated our findings against clinical studies data and bioinformatics studies. Our method offers a new insight into the molecular details of the disease and into potentially new therapy targets for it. Our approach for drug repurposing is significant beyond COVID-19 and may be applied also to other diseases.