FRESC: French Real world Extensive stage SCLC Cohorts: A retrospective study on patient characteristics and treatment strategy based on KBP-2010. (February 2022)

• Record Type: Journal Article
• Authors: Debieuvre, Didier; Dayen, Charles; Dixmier, Adrien; Pau, David; Sibley-Revelat, Anna; Greenwood, William; Gally, Samuel; Falchero, Lionel
• Is Part Of: Lung cancer. Volume 164(2022)
• Page Start: 1
• Page End: 7
• Publication Date: 2022-02
• Subjects: Extensive Stage Small Cell Lung Carcinoma -- Etoposide -- Platinum -- Overall survival -- First line therapy -- Secondary data used research -- KBP-2010 -- French cohorts -- FRESC; Lungs -- Cancer -- Periodicals; Lung Neoplasms -- Abstracts; Lung Neoplasms -- Periodicals; Poumons -- Cancer -- Périodiques; Lungs -- Cancer; Periodicals; Electronic journals; Electronic journals; 616.99424
• DOI: 10.1016/j.lungcan.2021.11.013
• Languages: English
• ISSNs: 0169-5002

Abstract

Highlights: French real world study reviewed first-line extensive-stage SCLC patient data from national real world data cohort. Participating non-academic hospitals mainly used standard-of-care platinum and etoposide chemotherapy. Patients receiving cisplatin + etoposide were younger and fitter than those receiving carboplatin + etoposide. Median OS of chemotherapy-treated first-line extensive-stage SCLC patients varied from 7 to 10 months. Patients treated with cisplatin + etoposide showed better OS and 1 year survival rates. Abstract: Objectives: FRESC reanalyzed extensive-stage small-cell lung cancer (ES-SCLC) patient data from the French KBP-2010 cohort to describe the characteristics and therapeutic management of ES-SCLC and provide real-world estimates of survival. Methods: A target population of first line (1L) ES-SCLC was identified at initial diagnosis in KBP-2010 ( KBP population, N = 796 ). A KBP-2010 subpopulation was defined as patients who also met the IMpower133 clinical trial PS ≤ 1 inclusion criteria ( KBP-PS_0/1 population, N = 394 ). Subgroups were defined according to the 1L ES-SCLC chemotherapy regimens: carboplatin or cisplatin with etoposide (Carb-E or Cisp-E subgroups). Results: The vast majority of KBP populations exhibited stage IV ES-SCLC (84.9%) at initial diagnosis. Median age was 66 years; patients were mostly male and smokers. Patients receiving Cisp + Eto were younger (median age 61 years [55.0–67.0]) and fitter (25.5% had PS ≥ 2) than those receiving Carb + Eto (71 years [62.5–77.5]; 44.1% had PS ≥ 2). Median overall survival (OS) of chemotherapy-treated 1L ES-SCLC patients varied from 7.0 months [95% CI, 6.1; 7.8] in the KBP Carb-E subgroups to 9.6 months [95% CI, 8.4; 10.8] in the KBP Cisp-E subgroup. KBP-PS_0/1 population showed better median OS, especially for the Cisp-E subgroup (10 months [95% CI, 8.7; 11.3]). Conclusion: In the KBP-PS_0/1 population, median OS was close to the one that was found in the IMpower133 control arm. Although this needs to be confirmed by further research, it suggests the transposability of the IMpower133 results to real-life conditions.