Chemical constituents from marine derived fungus Talaromyces cellulolyticus SHJ-3 and its chemotaxonomic significance. (February 2022)

• Record Type: Journal Article
• Authors: Xu, Hang; Zhou, Le; Wang, Meizhi; Wei, Lina; Qu, Haijun; Ma, Junying; Ju, Jianhua; Han, Zhiwu
• Is Part Of: Biochemical systematics and ecology. Volume 100(2022)
• Publication Date: 2022-02
• Subjects: Talaromyces cellulolyticus -- Molecular networking -- Chemotaxonomy -- Chrodrimanin; Chemotaxonomy -- Periodicals; Biochemical variation -- Periodicals; Ecology -- Periodicals; Biochemistry -- Periodicals; Ecology -- Periodicals; Chimiotaxinomie -- Périodiques; Variation biochimique -- Périodiques; Écologie -- Périodiques; 578.012
• DOI: 10.1016/j.bse.2021.104377
• Languages: English
• ISSNs: 0305-1978

Abstract

Abstract: Based on the MS/MS molecular networking target separation strategy, chemical investigation of the ethyl acetate extract of the marine coral derived fungus Talaromyces cellulolyticus SHJ-3 afforded a series of chrodrimanin meroterpenoids, namely, verruculide A (1 ), chrodrimanin A (2 ), chrodrimanin B (3 ), chrodrimanin C (4 ), chrodrimanin F (5 ), chrodrimanin H (6 ), along with two phenolic structures, 6-hydroxymellein (7 ) and N -(4-hydroxy-2-methoxyphenyl) acetamide (8 ). Their chemical structures were elucidated via NMR spectroscopic analysis, HRESIMS experiment, single-crystal X-ray diffraction, and compared with those reported in the literature. Among them, compound 7 was isolated from the genus of Talaromyces for the first time. Additionally, the chemotaxonomic significance of these compounds was also discussed. Overall, this work will enrich the chemical diversity and provide useful information for chemotaxonomic study on the genus of Talaromyces . Graphical abstract: Image 1 Highlights: Eight compounds, including six chrodrimanin meroterpenoids have been obtained from the fungus T. cellulolyticus. MS/MS molecular networking target separation strategy was applied. These structures were identified by spectroscopic methods. Chrodrimanin meroterpenoids can be considered as important chemotaxonomic markers of the genus Talaromyces.