Anti-neuroinflammatory oleanane-type triterpenoids from the seeds of Quercus serrata Thunb. (February 2022)

• Record Type: Journal Article
• Authors: Zhang, Wenxiang; Qin, Qiuyi; Wang, Yihai; Zeng, Jia; Mai, Yongxin; Xu, Jingwen; He, Xiangjiu
• Is Part Of: Phytochemistry letters. Volume 47(2022)
• Page Start: 67
• Page End: 75
• Publication Date: 2022-02
• Subjects: Quercus serrata Thunb. -- Chinese acorns -- Oleanane-type triterpenoids -- Anti-neuroinflammatory -- BV-2; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2021.11.005
• Languages: English
• ISSNs: 1874-3900

Abstract

Graphical abstract: Highlights: A study of the anti-neuroinflammtory effects of triterpenoids of the seeds of Quercus serrata were conducted. Seven new and eleven known oleanane-type triterpenoids were isolated and identified. Some of the triterpenoids showed potent anti-neuroinflammatory activities. Abstract: Chinese oak ( Quercus serrata Thunb.) is widely distributed throughout China and plays an important role as a building material. Its seeds (acorns) have served as a traditional herbal medicine in East Asia. Eighteen oleanane-type triterpenoids, including seven previously undescribed (1, 2, and 4–8 ) and eleven known triterpenoids, were isolated and identified from acorns. Their structures were elucidated using various spectroscopic and chemical methods. All isolated triterpenoids were screened for anti-neuroinflammatory effects by measuring their abilities to inhibit nitric oxide (NO) production in lipopolysaccharide (LPS)-induced BV-2 microglial cells, and most of the triterpenoids exhibited obvious anti-neuroinflammatory activity. Among them, Compounds 1 and 5 exhibited the strongest NO inhibitory activity, reduced the expression of inflammatory cytokines (iNOS, COX-2, and TNF-α), and blocked the nuclear translocation of NF-κB.