Nanoparticle theranostics in cardiovascular inflammation. (August 2021)

• Record Type: Journal Article
• Authors: MacRitchie, Neil; Di Francesco, Valentina; Ferreira, Miguel Filipe Moreira Marques; Guzik, Tomasz J.; Decuzzi, Paolo; Maffia, Pasquale
• Is Part Of: Seminars in immunology. Volume 56(2021)
• Publication Date: 2021-08
• Subjects: 99mTc 99m-technetium -- AAA abdominal aortic aneurysm -- apoE−/− apoloporotein-E -- CANTOS Canakinumab Anti-inflammatory Thrombosis Outcomes Study -- CCR5 C-C chemokine receptor type 5 -- CVD cardiovascular diseases -- CIRT Cardiovascular Inflammation Reduction Trial -- CITE-seq cellular indexing of transcriptomes and epitopes by sequencing -- COLCOT Colchicine Cardiovascular Outcomes Trial -- CT computed tomography -- CyTOF cytometry by time of flight -- DDS drug delivery systems -- DCE-MRI dynamic contrast enhanced MRI -- EPR enhanced permeability and retention -- FN-EDB extra domain B of fibronectin -- FDA Food and Drug Administration -- Gd3+ gadolinium -- HDL high-density lipoprotein -- HDL-MNS high-density lipoprotein-like magnetic nanostructures -- hs-CRP high-sensitivity C-reactive protein -- H2O2 hydrogen peroxide -- ICAM-1 intercellular adhesion molecule-1 -- IL-6 interleukin-6 -- IPAI intravascular photoacoustic imaging -- IVUS intravascular ultrasound -- LoDoCo2 low-dose colchicine 2 -- MPI magnetic particle imaging -- MRI magnetic resonance imaging -- MACE major adverse cardiac events -- MMPs matrix metalloproteinases -- MTX mitoxantrone -- MSOT multispectral optoacoustic tomography -- MPO myeloperoxidase -- MI myocardial infarction -- NP nanoparticle -- NPRC natriuretic peptide receptor C -- NIR near-infrared -- PFCs perfluorocarbons -- PAI photoacoustic imaging -- PDT photodynamic therapy -- PTT photothermal therapy -- PLGA poly(lactic acid), poly(lactic-co-glycolic acid) -- PEG polyethylene glycol -- PET positron Emission Tomography -- PLP prednisolone phosphate -- PCSK9 proprotein convertase subtilisin-kexin type 9 -- PGI2 prostacycline -- QD quantum dots -- RAGE receptor for advanced glycation end-products -- RES reticuloendothelial system -- SR-A scavenger receptor-A -- scRNA-seq single-cell RNA sequencing -- SPECT single-photon emission computed tomography -- SPR surface plasmon resonance -- SERS surface-enhanced Raman spectroscopy -- USPIO ultra-small superparamagnetic iron oxide -- VCAM-1 vascular cell adhesion molecule 1; Atherosclerosis -- Cardiovascular disease -- Inflammation -- Myocardial infarction -- Nanoparticles -- Theranostics; Immunology -- Periodicals; Allergy and Immunology -- Periodicals; Immunity -- Periodicals; Immunologie -- Périodiques; Electronic journals; 616.079
• DOI: 10.1016/j.smim.2021.101536
• Languages: English
• ISSNs: 1044-5323

Abstract

Abstract: Theranostics, literally derived from the combination of the words diagnostics and therapy, is an emerging field of clinical and preclinical research, where contrast agents, drugs and diagnostic techniques are combined to simultaneously diagnose and treat pathologies. Nanoparticles are extensively employed in theranostics due to their potential to target specific organs and their multifunctional capacity. In this review, we will discuss the current state of theranostic nanomedicine, providing key examples of its application in the imaging and treatment of cardiovascular inflammation.