Geoeconomic variations in epidemiology, ventilation management, and outcomes in invasively ventilated intensive care unit patients without acute respiratory distress syndrome: a pooled analysis of four observational studies. Issue 2 (February 2022)

• Record Type: Journal Article
• Authors: Pisani, Luigi; Algera, Anna Geke; Neto, Ary Serpa; Azevedo, Luciano; Pham, Tài; Paulus, Frederique; de Abreu, Marcelo Gama; Pelosi, Paolo; Dondorp, Arjen M; Bellani, Giacomo; Laffey, John G; Schultz, Marcus J; Martinez, Amadeu; Leal, Livia; Jorge Pereira, Antonio; de Oliveira Maia, Marcelo; Neto, Josè Aires; Piras, Claudio; Caser, Eliana Bernadete; Moreira, Cora Lavigne; Braga Gusman, Pablo; Dalcomune, Dyanne Moysés; Ribeiro de Carvalho, Alexandre Guilherme; Gondim, Louise Aline Romão; Castelo Branco Reis, Lívia Mariane; da Cunha Ribeiro, Daniel; de Assis Simões, Leonardo; Campos, Rafaela Siqueira; Fernandez Versiani dos Anjos, José Carlos; Bruzzi Carvalho, Frederico; Alves, Rossine Ambrosio; Nunes, Lilian Batista; Réa-Neto, Álvaro; de Oliveira, Mirella Cristine; Tannous, Luana; Cardoso Gomes, Brenno; Rodriguez, Fernando Borges; Abelha, Priscila; Lugarinho, Marcelo E; Japiassu, Andre; de Melo, Hélder Konrad; Lopes, Elton Afonso; Varaschin, Pedro; de Souza Dantas, Vicente Cés; Freitas Knibel, Marcos; Ponte, Micheli; de Azambuja Rodrigues, Pedro Mendes; Costa Filho, Rubens Carmo; Saddy, Felipe; Wanderley Castellões, Théia Forny; Silva, Suzana Alves; Osorio, Luiz Antonio Gomes; Mannarino, Dora; Espinoza, Rodolfo; Righy, Cassia; Soares, Marcio; Salluh, Jorge; Tanaka, Lilian; Aragão, Daniel; Tavares, Maria Eduarda; Kehdi, Maura Goncalves Pereira; Rezende, Valéria Maria Campos; Carbonell, Roberto Carlos Cruz; Teixeira, Cassiano; de Oliveira, Roselaine Pinheiro; Maccari, Juçara Gasparetto; Castro, Priscylla Souza; Berto, Paula; Schwarz, Patricia; Torelly, André Peretti; Lisboa, Thiago; Moraes, Edison; Dal-Pizzol, Felipe; Tomasi Damiani, Cristiane; Ritter, Cristiane; Ferreira, Juliana Carvalho; Teixeira Costa, Ramon; Caruso, Pedro; Amendola, Cristina Prata; de Oliveira, Amanda Maria R R; Silva, Ulysses V A; Sanches, Luciana Coelho; Almeida, Rosana D S; Azevedo, Luciano Cesar; Park, Marcelo; Schettino, Guilherme; Assunção, Murillo Santucci; Silva, Eliezer; Barboza, Carlos Eduardo; Junior, Antonio Paulo Nassar; Marzocchi Tierno, Paulo Fernando G M; Malbouisson, Luis Marcelo; Oliveira, Lucas; Cristovao, Davi; Neto, Manoel Leitão; Rego, Ênio; Fernandes, Fernanda Eugênia; Romano, Marcelo Luz Pereira; Cavalcanti, Alexandre Biasi; de Souza Barros, Dalton; Suzumura, Érica Aranha; Meira, Karla Loureiro; de Oliveira, Gustavo Affonso; Luciano, Paula Menezes; Pacheco, Evelin Drociunas; Mazza, Bruno Franco; Machado, Flavia Ribeiro; Ferreira, Elaine; dos Santos, Ronaldo Batista; Colombo, Alexandra Siqueira; Nogueira, Antonio Carlos; Fernandes, Juliana Baroni; Nóbrega, Raquel Siqueira; do CS Martins, Barbara; Soriano, Francisco; Morsch, Rafaela Deczka; Nunes, Andre Luiz Baptiston; de Almeida, Juliano Pinheiro; Hajjar, Ludhmila; Moulin, Sílvia; Giannini, Fábio Poianas; Baptiston Nunes, Andre Luiz; Rios, Fernando; Van Haren, Frank; Sottiaux, T; Lora, Fredy S; Azevedo, Luciano C; Depuydt, P; Fan, Eddy; Bugedo, Guillermo; Qiu, Haibo; Gonzalez, Marcos; Silesky, Juan; Cerny, Vladimir; Nielsen, Jonas; Jibaja, Manuel; Pham, Tài; Wrigge, Hermann; Matamis, Dimitrios; Ranero, Jorge Luis; Hashemian, S M; Amin, Pravin; Clarkson, Kevin; Bellani, Giacomo; Kurahashi, Kiyoyasu; Villagomez, Asisclo; Zeggwagh, Amine Ali; Heunks, Leo M; Laake, Jon Henrik; Palo, Jose Emmanuel; do Vale Fernandes, Antero; Sandesc, Dorel; Arabi, Yaasen; Bumbasierevic, Vesna; Lorente, Jose A; Larsson, Anders; Piquilloud, Lise; Abroug, Fekri; McAuley, Daniel F; McNamee, Lia; Hurtado, Javier; Bajwa, Ed; Démpaire, Gabriel; Francois, Guy M; Sula, Hektor; Nunci, Lordian; Cani, Alma; Zazu, Alan; Dellera, Christian; Insaurralde, Carolina S; Alejandro, Risso V; Daldin, Julio; Vinzio, Mauricio; Fernandez, Ruben O; Cardonnet, Luis P; Bettini, Lisandro R; Bisso, Mariano Carboni; Osman, Emilio M; Setten, Mariano G; Lovazzano, Pablo; Alvarez, Javier; Villar, Veronica; Milstein, Cesar; Pozo, Norberto C; Grubissich, Nicolas; Plotnikow, Gustavo A; Vasquez, Daniela N; Ilutovich, Santiago; Tiribelli, Norberto; Chena, Ariel; Pellegrini, Carlos A; Saenz, María G; Estenssoro, Elisa; Brizuela, Matias; Gianinetto, Hernan; Gomez, Pablo E; Cerrato, Valeria I; Bezzi, Marco G; Borello, Silvina A; Loiacono, Flavia A; Fernandez, Adriana M; Knowles, Serena; Reynolds, Claire; Inskip, Deborah M; Miller, Jennene J; Kong, Jing; Whitehead, Christina; Bihari, Shailesh; Seven, Aylin; Krstevski, Amanda; Rodgers, Helen J; Millar, Rebecca T; Mckenna, Toni E; Bailey, Irene M; Hanlon, Gabrielle C; Aneman, Anders; Lynch, Joan M; Azad, Raman; Neal, John; Woods, Paul W; Roberts, Brigit L; Kol, Mark R; Wong, Helen S; Riss, Katharina C; Staudinger, Thomas; Wittebole, Xavier; Berghe, Caroline; Bulpa, Pierre A; Dive, Alain M; Verstraete, Rik; Lebbinck, Herve; Depuydt, Pieter; Vermassen, Joris; Meersseman, Philippe; Ceunen, Helga; Rosa, Jonas I; Beraldo, Daniel O; Piras, Claudio; Ampinelli, Adenilton M R; Nassar Jr, Antonio P; Mataloun, Sergio; Moock, Marcelo; Thompson, Marlus M; Gonçalves, Claudio H; Antônio, Ana Carolina P; Ascoli, Aline; Biondi, Rodrigo S; Fontenele, Danielle C; Nobrega, Danielle; Sales, Vanessa M; Shindhe, Suresh; Ismail, Dk Maizatul Aiman B Pg Hj; Laffey, John; Beloncle, Francois; Davies, Kyle G; Cirone, Rob; Manoharan, Venika; Ismail, Mehvish; Goligher, Ewan C; Jassal, Mandeep; Nishikawa, Erin; Javeed, Areej; Curley, Gerard; Rittayamai, Nuttapol; Parotto, Matteo; Ferguson, Niall D; Mehta, Sangeeta; Knoll, Jenny; Pronovost, Antoine; Canestrini, Sergio; Bruhn, Alejandro R; Garcia, Patricio H; Aliaga, Felipe A; Farías, Pamela A; Yumha, Jacob S; Ortiz, Claudia A; Salas, Javier E; Saez, Alejandro A; Vega, Luis D; Labarca, Eduardo F; Martinez, Felipe T; Carreño, Nicolás G; Lora, Pilar; Liu, Haitao; Qiu, Haibo; Liu, Ling; Tang, Rui; Luo, Xiaoming; An, Youzhong; Zhao, Huiying; Gao, Yan; Zhai, Zhe; Ye, Zheng L; Wang, Wei; Li, Wenwen; Li, Qingdong; Zheng, Ruiqiang; Yu, Wenkui; Shen, Juanhong; Li, Xinyu; Yu, Tao; Lu, Weihua; Wu, Ya Q; Huang, Xiao B; He, Zhenyang; Lu, Yuanhua; Han, Hui; Zhang, Fan; Sun, Renhua; Wang, Hua X; Qin, Shu H; Zhu, Bao H; Zhao, Jun; Liu, Jian; Li, Bin; Liu, Jing L; Zhou, Fa C; Li, Qiong J; Zhang, Xing Y; Li-Xin, Zhou; Xin-Hua, Qiang; Jiang, Liangyan; Gao, Yuan N; Zhao, Xian Y; Li, Yuan Y; Li, Xiao L; Wang, Chunting; Yao, Qingchun; Yu, Rongguo; Chen, Kai; Shao, Huanzhang; Qin, Bingyu; Huang, Qing Q; Zhu, Wei H; Hang, Ai Y; Hua, Ma X; Li, Yimin; Xu, Yonghao; Di, Yu D; Ling, Long L; Qin, Tie H; Wang, Shou H; Qin, Junping; Han, Yi; Zhou, Suming; Vargas, Monica P; Silesky Jimenez, Juan I; González Rojas, Manuel A; Solis-Quesada, Jaime E; Ramirez-Alfaro, Christian M; Máca, Jan; Sklienka, Peter; Gjedsted, Jakob; Christiansen, Aage; Nielsen, Jonas; Villamagua, Boris G; Llano, Miguel; Burtin, Philippe; Buzancais, Gautier; Beuret, Pascal; Pelletier, Nicolas; Mortaza, Satar; Mercat, Alain; Chelly, Jonathan; Jochmans, Sébastien; Terzi, Nicolas; Daubin, Cédric; Carteaux, Guillaume; de Prost, Nicolas; Chiche, Jean-Daniel; Daviaud, Fabrice; Pham, Tai; Fartoukh, Muriel; Barberet, Guillaume; Biehler, Jerome; Dellamonica, Jean; Doyen, Denis; Arnal, Jean-Michel; Briquet, Anais; Hraiech, Sami; Papazian, Laurent; Follin, Arnaud; Roux, Damien; Messika, Jonathan; Kalaitzis, Evangelos; Dangers, Laurence; Combes, Alain; Au, Siu-Ming; Béduneau, Gaetan; Carpentier, Dorothée; Zogheib, Elie H; Dupont, Herve; Ricome, Sylvie; Santoli, Francesco L; Besset, Sebastien L; Michel, Philippe; Gelée, Bruno; Danin, Pierre-Eric; Goubaux, Bernard; Crova, Philippe J; Phan, Nga T; Berkelmans, Frantz; Badie, Julio C; Tapponnier, Romain; Gally, Josette; Khebbeb, Samy; Herbrecht, Jean-Etienne; Schneider, Francis; Declercq, Pierre-Louis M; Rigaud, Jean-Philippe; Duranteau, Jacques; Harrois, Anatole; Chabanne, Russell; Marin, Julien; Bigot, Charlene; Thibault, Sandrine; Ghazi, Mohammed; Boukhazna, Messabi; Ould Zein, Salem; Richecoeur, Jack R; Combaux, Daniele M; Grelon, Fabien; Le Moal, Charlene; Sauvadet, Elise P; Robine, Adrien; Lemiale, Virginie; Reuter, Danielle; Dres, Martin; Demoule, Alexandre; Goldgran-Toledano, Dany; Baboi, Loredana; Guérin, Claude; Lohner, Ralph; Kraßler, Jens; Schäfer, Susanne; Zacharowski, Kai D; Meybohm, Patrick; Reske, Andreas W; Simon, Philipp; Hopf, Hans-Bernd F; Schuetz, Michael; Baltus, Thomas; Papanikolaou, Metaxia N; Papavasilopoulou, Theonymfi G; Zacharas, Giannis A; Ourailogloy, Vasilis; Mouloudi, Eleni K; Massa, Eleni V; Nagy, Eva O; Stamou, Electra E; Kiourtzieva, Ellada V; Oikonomou, Marina A; Avila, Luis E; Cortez, Cesar A; Citalán, Johanna E; Jog, Sameer A; Sable, Safal D; Shah, Bhagyesh; Gurjar, Mohan; Baronia, Arvind K; Memon, Mohammedfaruk; Muthuchellappan, Radhakrishnan; Ramesh, Venkatapura J; Shenoy, Anitha; Unnikrishnan, Ramesh; Dixit, Subhal B; Rhayakar, Rachana V; Ramakrishnan, Nagarajan; Bhardwaj, Vallish K; Mahto, Heera L; Sagar, Sudha V; Palaniswamy, Vijayanand; Ganesan, Deeban; Mohammadreza Hashemian, Seyed; Jamaati, Hamidreza; Heidari, Farshad; Meaney, Edel A; Nichol, Alistair; Knapman, Karl M; O'Croinin, Donall; Dunne, Eimhin S; Breen, Dorothy M; Clarkson, Kevin P; Jaafar, Rola F; Dwyer, Rory; Amir, Fahd; Ajetunmobi, Olaitan O; O'Muircheartaigh, Aogan C; Black, Colin S; Treanor, Nuala; Collins, Daniel V; Altaf, Wahid; Zani, Gianluca; Fusari, Maurizio; Spadaro, Savino; Volta, Carlo A; Graziani, Romano; Brunettini, Barbara; Palmese, Salvatore; Formenti, Paolo; Umbrello, Michele; Lombardo, Andrea; Pecci, Elisabetta; Botteri, Marco; Savioli, Monica; Protti, Alessandro; Mattei, Alessia; Schiavoni, Lorenzo; Tinnirello, Andrea; Todeschini, Manuel; Giarratano, Antonino; Cortegiani, Andrea; Sher, Sara; Rossi, Anna; Antonelli, Massimo M; Montini, Luca M; Casalena, Paolo; Scafetti, Sergio; Panarello, Giovanna; Occhipinti, Giovanna; Patroniti, Nicolò; Pozzi, Matteo; Biscione, Roberto R; Poli, Michela M; Raimondi, Ferdinando; Albiero, Daniela; Crapelli, Giulia; Beck, Eduardo; Pota, Vincenzo; Schiavone, Vincenzo; Molin, Alexandre; Tarantino, Fabio; Monti, Giacomo; Frati, Elena; Mirabella, Lucia; Cinnella, Gilda; Fossali, Tommaso; Colombo, Riccardo; Terragni, Pierpaolo; Pattarino, Ilaria; Mojoli, Francesco; Braschi, Antonio; Borotto, Erika E; Cracchiolo, Andrea N; Palma, Daniela M; Raponi, Francesco; Foti, Giuseppe; Vascotto, Ettore R; Coppadoro, Andrea; Brazzi, Luca; Floris, Leda; Iotti, Giorgio A; Venti, Aaron; Yamaguchi, Osamu; Takagi, Shunsuke; Maeyama, Hiroki N; Watanabe, Eizo; Yamaji, Yoshihiro; Shimizu, Kazuyoshi; Shiozaki, Kyoko; Futami, Satoru; Ryosuke, Sekine; Saito, Koji; Kameyama, Yoshinobu; Ueno, Keiko; Izawa, Masayo; Okuda, Nao; Suzuki, Hiroyuki; Harasawa, Tomofumi; Nasu, Michitaka; Takada, Tadaaki; Ito, Fumihito; Nunomiya, Shin; Koyama, Kansuke; Abe, Toshikazu; Andoh, Kohkichi; Kusumoto, Kohei; Hirata, Akira; Takaba, Akihiro; Kimura, Hiroyasu; Matsumoto, Shuhei; Higashijima, Ushio; Honda, Hiroyuki; Aoki, Nobumasa; Imai, Hiroshi; Ogino, Yasuaki; Mizuguchi, Ichiko; Ichikado, Kazuya; Nitta, Kenichi; Mochizuki, Katsunori; Hashida, Tomoaki; Tanaka, Hiroyuki; Nakamura, Tomoyuki; Niimi, Daisuke; Ueda, Takeshi; Kashiwa, Yozo; Uchiyama, Akinori; Sabelnikovs, Olegs; Oss, Peteris; Haddad, Youssef; Liew, Kong Y; Ñamendys-Silva, Silvio A; Jarquin-Badiola, Yves D; Sanchez-Hurtado, Luis A; Gomez-Flores, Saira S; Marin, Maria C; Villagomez, Asisclo J; Lemus, Jordana S; Fierro, Jonathan M; Cervantes, Mavy Ramirez; Mejia, Francisco Javier Flores; Gonzalez, Daniel R; Dector, Dulce M; Estrella, Claudia R; Sanchez-Medina, Jorge R; Ramirez-Gutierrez, Alvaro; George, Fernando G; Aguirre, Janet S; Buensuseso, Juan A; Poblano, Manuel; Dendane, Tarek; Zeggwagh, Amine Ali; Balkhi, Hicham; Elkhayari, Mina; Samkaoui, Nacer; Ezzouine, Hanane; Benslama, Abdellatif; Amor, Mourad; Maazouzi, Wajdi; Cimic, Nedim; Beck, Oliver; Bruns, Monique M; Schouten, Jeroen A; Rinia, Myra; Raaijmakers, Monique; Heunks, Leo M; Van Wezel, Hellen M; Heines, Serge J; Buise, Marc P; Simonis, Fabienne D; Schultz, Marcus J; Goodson, Jennifer C; rowne, Troy S B; Navarra, Leanlove; Hunt, Anna; Hutchison, Robyn A; Bailey, Mathew B; Newby, Lynette; Mcarthur, Colin; Kalkoff, Michael; Mcleod, Alex; Casement, Jonathan; Hacking, Danielle J; Andersen, Finn H; Dolva, Merete S; Laake, Jon H; Barratt-Due, Andreas; Noremark, Kim Andre L; Søreide, Eldar; Sjøbø, Brit Å; Guttormsen, Anne B; Yoshido, Hector H Leon; Aguilar, Ronald Zumaran; Oscanoa, Fredy A Montes; Alisasis, Alain U; Robles, Joanne B; Pasanting-Lim, Rossini Abbie B; Tan, Beatriz C; Andruszkiewicz, Pawel; Jakubowska, Karina; Cox, Cristina M; Alvarez, António M; Oliveira, Bruno S; Montanha, Gustavo M; Barros, Nelson C; Pereira, Carlos S; Messias, António M; Monteiro, Jorge M; Araujo, Ana M; Catorze, Nuno T; Marum, Susan M; Bouw, Maria J; Gomes, Rui M; Brito, Vania A; Castro, Silvia; Estilita, Joana M; Barros, Filipa M; Serra, Isabel M; Martinho, Aurelia M; Tomescu, Dana R; Marcu, Alexandra; Bedreag, Ovidiu H; Papurica, Marius; Corneci, Dan E; Negoita, Silvius Ioan; Grigoriev, Evgeny; Gritsan, Alexey I; Gazenkampf, Andrey A; Almekhlafi, Ghaleb; Albarrak, Mohamad M; Mustafa, Ghanem M; Maghrabi, Khalid A; Salahuddin, Nawal; Aisa, Tharwat M; Al Jabbary, Ahmed S; Tabhan, Edgardo; Arabi, Yaseen M; Trinidad, Olivia A; Al Dorzi, Hasan M; Tabhan, Edgardo E; Bolon, Stefan; Smith, Oliver; Mancebo, Jordi; Aguirre-Bermeo, Hernan; Lopez-Delgado, Juan C; Esteve, Francisco; Rialp, Gemma; Forteza, Catalina; De Haro, Candelaria; Artigas, Antonio; Albaiceta, Guillermo M; De Cima-Iglesias, Sara; Seoane-Quiroga, Leticia; Ceniceros-Barros, Alexandra; Ruiz-Aguilar, Antonio L; Claraco-Vega, Luis M; Soler, Juan Alfonso; Lorente, Maria del Carmen; Hermosa, Cecilia; Gordo, Federico; Prieto-González, Miryam; López-Messa, Juan B; Perez, Manuel P; Pere, Cesar P; Allue, Raquel Montoiro; Roche-Campo, Ferran; Ibañez-Santacruz, Marcos; Temprano, Susana; Pintado, Maria C; De Pablo, Raul; Gómez, Pilar Ricart Aroa; Ruiz, Silvia Rodriguez; Moles, Silvia Iglesias; Jurado, Mª Teresa; Arizmendi, Alfons; Piacentini, Enrique A; Franco, Nieves; Honrubia, Teresa; Perez Cheng, Meisy; Perez Losada, Elena; Blanco, Javier; Yuste, Luis J; Carbayo-Gorriz, Cecilia; Cazorla-Barranquero, Francisca G; Alonso, Javier G; Alda, Rosa S; Algaba, Ángela; Navarro, Gonzalo; Cereijo, Enrique; Diaz-Rodriguez, Esther; Marcos, Diego Pastor; Montero, Laura Alvarez; Para, Luis Herrera; Sanchez, Roberto Jimenez; Blasco Navalpotro, Miguel Angel; Abad, Ricardo Diaz; Montiel González, Raquel; Toribio, Dácil Parrilla; Castro, Alejandro G; Artiga, Maria Jose D; Penuelas, Oscar; Roser, Tomas P; Olga, Moreno F; Curto, Elena Gallego; Sánchez, Rocío Manzano; Imma, Vallverdu P; Elisabet, Garcia M; Claverias, Laura; Magret, Monica; Pellicer, Ana M; Rodriguez, Lucia L; Sánchez-Ballesteros, Jesús; González-Salamanca, Ángela; Jimenez, Antonio G; Huerta, Francisco P; Diaz, Juan Carlos J Sotillo; Lopez, Esther Bermejo; Moya, David D Llinares; Alfonso, Alec A Tallet; Eugenio Luis, Palazon Sanchez; Cesar, Palazon Sanchez; Rafael, Sánchez I; Virgilio, Corcoles G; Recio, Noelia N; Adamsson, Richard O; Rylander, Christian C; Holzgraefe, Bernhard; Broman, Lars M; Wessbergh, Joanna; Persson, Linnea; Schiöler, Fredrik; Kedelv, Hans; Tibblin, Anna Oscarsson; Appelberg, Henrik; Hedlund, Lars; Helleberg, Johan; Eriksson, Karin E; Glietsch, Rita; Larsson, Niklas; Nygren, Ingela; Nunes, Silvia L; Morin, Anna-Karin; Kander, Thomas; Adolfsson, Anne; Piquilloud, Lise; Zender, Hervé O; Leemann-Refondini, Corinne; Elatrous, Souheil; Bouchoucha, Slaheddine; Chouchene, Imed; Ouanes, Islem; Ben Souissi, Asma; Kamoun, Salma; Demirkiran, Oktay; Aker, Mustafa; Erbabacan, Emre; Ceylan, Ilkay; Girgin, Nermin Kelebek; Ozcelik, Menekse; Ünal, Necmettin; Meco, Basak Ceyda; Akyol, Onat O; Derman, Suleyman S; Kennedy, Barry; Parhar, Ken; Srinivasa, Latha; McNamee, Lia; McAuley, Danny; Steinberg, Jack; Hopkins, Phil; Mellis, Clare; Stansil, Frank; Kakar, Vivek; Hadfield, Dan; Brown, Christine; Vercueil, Andre; Bhowmick, Kaushik; Humphreys, Sally K; Ferguson, Andrew; Mckee, Raymond; Raj, Ashok S; Fawkes, Danielle A; Watt, Philip; Twohey, Linda; Thomas, Rajeev R Jha Matthew; Morton, Alex; Kadaba, Varsha; Smith, Mark J; Hormis, Anil P; Kannan, Santhana G; Namih, Miriam; Reschreiter, Henrik; Camsooksai, Julie; Kumar, Alek; Rugonfalvi, Szabolcs; Nutt, Christopher; Oneill, Orla; Seasman, Colette; Dempsey, Ged; Scott, Christopher J; Ellis, Helen E; Mckechnie, Stuart; Hutton, Paula J; Di Tomasso, Nora N; Vitale, Michela N; Griffin, Ruth O; Dean, Michael N; Cranshaw, Julius H; Willett, Emma L; Ioannou, Nicholas; Gillis, Sarah; Csabi, Peter; Macfadyen, Rosaleen; Dawson, Heidi; Preez, Pieter D; Williams, Alexandra J; Boyd, Owen; De Gordoa, Laura Ortiz-Ruiz; Bramall, Jon; Symmonds, Sophie; Chau, Simon K; Wenham, Tim; Szakmany, Tamas; Toth-Tarsoly, Piroska; Mccalman, Katie H; Alexander, Peter; Stephenson, Lorraine; Collyer, Thomas; Chapman, Rhiannon; Cooper, Raphael; Allan, Russell M; Sim, Malcolm; Wrathall, David W; Irvine, Donald A; Zantua, Kim S; Adams, John C; Burtenshaw, Andrew J; Sellors, Gareth P; Welters, Ingeborg D; Williams, Karen E; Hessell, Robert J; Oldroyd, Matthew G; Battle, Ceri E; Pillai, Suresh; Kajtor, Istvan; Sivashanmugave, Mageswaran; Okane, Sinead C; Donnelly, Adrian; Frigyik, Aniko D; Careless, Jon P; May, Martin M; Stewart, Richard; Trinder, T John; Hagan, Samantha J; Wise, Matt P; Cole, Jade M; MacFie, Caroline C; Dowling, Anna T; Hurtado, Javier; Nin, Nicolás; Hurtado, Javier; Nuñez, Edgardo; Pittini, Gustavo; Rodriguez, Ruben; Imperio, María C; Santos, Cristina; França, Ana G; Ebeid, Alejandro; Deicas, Alberto; Serra, Carolina; Uppalapati, Aditya; Kamel, Ghassan; Banner-Goodspeed, Valerie M; Beitler, Jeremy R; Mukkera, Satyanarayana Reddy; Kulkarni, Shreedhar; Lee, Jarone; Mesar, Tomaz; Shinn Iii, John O; Gomaa, Dina; Tainter, Christopher; Mesar, Tomaz; Cowley, R Adams; Yeatts, Dale J; Warren, Jessica; Lanspa, Michael J; Miller, Russel R; Grissom, Colin K; Brown, Samuel M; Bauer, Philippe R; Gosselin, Ryan J; Kitch, Barrett T; Cohen, Jason E; Beegle, Scott H; Gueret, Renaud M; Tulaimat, Aiman; Choudry, Shazia; Stigler, William; Batra, Hitesh; Huff, Nidhi G; Lamb, Keith D; Oetting, Trevor W; Mohr, Nicholas M; Judy, Claine; Saito, Shigeki; Kheir, Fayez M; Schlichting, Adam B; Delsing, Angela; Elmasri, Mary; Crouch, Daniel R; Ismail, Dina; Blakeman, Thomas C; Dreyer, Kyle R; Gomaa, Dina; Baron, Rebecca M; Grijalba, Carolina Quintana; Hou, Peter C; Seethala, Raghu; Aisiku, Imo; Henderson, Galen; Frendl, Gyorgy; Hou, Sen-Kuang; Owens, Robert L; Schomer, Ashley; Bumbasirevic, Vesna; Jovanovic, Bojan; Surbatovic, Maja; Veljovic, Milic; Van Haren, Frank; Rodgers, Helen; Dixon, Barry; Smith, Roger; Kol, Mark; Wong, Helen; Schmid, Werner; Hermans, Greet; Ceunen, Helga; Bourgeois, Marc; Anquez, Nathalie; Decruyenaere, Johan; DeCrop, Luc; Neto, Ary Serpa; Souza dos Santos, Rafaella; Beraldo, Daniel; dos Santos, Moreno Calcagnotto; Pellegrini, Jose Augusto Santos; Piras, Claudio; Oliveira, Vanessa; Munhoz, Carlos; Peçanha, Ana Carolina; da Silva Ramos, Fernando José; Maia, Israel; Bahl, Marina; Biondi, Rodrigo; Prado, Daniel; Pinto, Sérgio Felix; Salgado, Jean; Falcão, Luis Fernando; Macruz, Tiago; Cavalcanti, Alexandre Biasi; Romano, Marcelo Luz Pereira; Ruas, Kessia; Mecatti, Giovana Colozza; Caser, Eliane Bernadete; Gava, Isabela Ambrósio; Carreño, Nicolás; Morales, Mauricio; Avendaño, Rossana; Aguirre, Stefania; Sribar, Andrej; Klaric, Vlasta; Skilijic, Sonja; Dvorscak, Matea Bogdanovic; Krkusek, Marijana; Jurjevic, Matija; Karanovic, Nenad; Simurina, Tatjana; Stourac, Petr; Kratochvil, Milan; Máca, Jan; Wrigge, Hermann; Schlegel, Christian; Treschan, Tanja A; Schaefer, Maximilian; Aytulun, Akut; Kienbaum, Peter; Clarkson, Kevin; Jaafar, Rola; Collins, Daniel; Plant, Robert; Melchionda, Giuseppe; Di Lauro, Eduardo; Cortegiani, Andrea; Russotto, Vincenzo; Caione, Raffaele; Mestria, Donatella; Volta, Carlo Alberto; Spadaro, Savino; Botteri, Marco; Seghelini, Elisa; Brazzi, Luca; Sales, Gabriele; D'Antini, Davide; Molin, Alexandre; Severgnini, Paolo; Bacuzzi, Alessandro; Peluso, Lorenzo; Verrastro, Pasquale; Raimondo, Pasquale; Gecaj-Gashi, Agreta; Simonis, Fabienne D; 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• Is Part Of: Lancet. Volume 10:Issue 2(2022)
• Page Start: e227
• Page End: e235
• Publication Date: 2022-02
• Subjects: World health -- Periodicals; 362.105
• DOI: 10.1016/S2214-109X(21)00485-X
• Languages: English
• ISSNs: 2214-109X

Abstract

Summary: Background: Geoeconomic variations in epidemiology, the practice of ventilation, and outcome in invasively ventilated intensive care unit (ICU) patients without acute respiratory distress syndrome (ARDS) remain unexplored. In this analysis we aim to address these gaps using individual patient data of four large observational studies. Methods: In this pooled analysis we harmonised individual patient data from the ERICC, LUNG SAFE, PRoVENT, and PRoVENT-iMiC prospective observational studies, which were conducted from June, 2011, to December, 2018, in 534 ICUs in 54 countries. We used the 2016 World Bank classification to define two geoeconomic regions: middle-income countries (MICs) and high-income countries (HICs). ARDS was defined according to the Berlin criteria. Descriptive statistics were used to compare patients in MICs versus HICs. The primary outcome was the use of low tidal volume ventilation (LTVV) for the first 3 days of mechanical ventilation. Secondary outcomes were key ventilation parameters (tidal volume size, positive end-expiratory pressure, fraction of inspired oxygen, peak pressure, plateau pressure, driving pressure, and respiratory rate), patient characteristics, the risk for and actual development of acute respiratory distress syndrome after the first day of ventilation, duration of ventilation, ICU length of stay, and ICU mortality. Findings: Of the 7608 patients included in the original studies, this analysis included 3852 patients without ARDS, of whom 2345 were from MICs and 1507 were from HICs. Patients in MICs were younger, shorter and with a slightly lower body-mass index, more often had diabetes and active cancer, but less often chronic obstructive pulmonary disease and heart failure than patients from HICs. Sequential organ failure assessment scores were similar in MICs and HICs. Use of LTVV in MICs and HICs was comparable (42·4% vs 44·2%; absolute difference –1·69 [–9·58 to 6·11] p=0·67; data available in 3174 [82%] of 3852 patients). The median applied positive end expiratory pressure was lower in MICs than in HICs (5 [IQR 5–8] vs 6 [5–8] cm H2 O; p=0·0011). ICU mortality was higher in MICs than in HICs (30·5% vs 19·9%; p=0·0004; adjusted effect 16·41% [95% CI 9·52–23·52]; p<0·0001) and was inversely associated with gross domestic product (adjusted odds ratio for a US$10 000 increase per capita 0·80 [95% CI 0·75–0·86]; p<0·0001). Interpretation: Despite similar disease severity and ventilation management, ICU mortality in patients without ARDS is higher in MICs than in HICs, with a strong association with country-level economic status. Funding: No funding.