Resection of primary gastroenteropancreatic neuroendocrine tumors in the presence of irresectable liver metastases. (November 2016)

• Record Type: Journal Article
• Authors: Wadsworth, Philippa K; Jones, Robert P; Poston, Graeme J
• Is Part Of: International journal of endocrine oncology. Volume 3:Number 4(2016)
• Page Start: 291
• Page End: 297
• Publication Date: 2016-11
• Subjects: liver -- metastases -- primary -- surgery -- neuroendocrine; Endocrine glands -- Cancer -- Periodicals; 616.9944005
• DOI: 10.2217/ije-2016-0010
• Languages: English
• ISSNs: 2045-0869

Abstract

Gastroenteropancreatic neuroendocrine tumors often present at an advanced stage and carry a variable prognosis, with many patients living long periods even with metastatic disease. Resection of the primary tumor when liver metastases are unresectable is a contentious subject with no consensus between existing guidelines. A number of recent studies have suggested a potential survival benefit as well as improved symptom control with resection. With variable results from nonoperative management strategies, the risk:benefit ratio of resection of the primary tumor may be favorable for carefully selected patients.