Differential evolutionary dynamics of Enterovirus D68 from countries of different continents. (January 2017)

• Record Type: Journal Article
• Authors: Li, Jianguo; Hao, Chunyan; Liu, Xianjun; Qin, Xuemei
• Is Part Of: Future virology. Volume 12:Number 1(2017)
• Page Start: 29
• Page End: 35
• Publication Date: 2017-01
• Subjects: bottleneck -- enterovirus D68 -- phylodynamics; Virology -- Periodicals; Virus diseases -- Treatment -- Periodicals; 616.9101
• DOI: 10.2217/fvl-2016-0092
• Languages: English
• ISSNs: 1746-0794

Abstract

Aim: To explore the underlying genetic reasons of Enterovirus D68 (EV-D68) for its differential epidemiological patterns among continents.Materials & methods: Four hundred and sixty complete VP1 sequences of EV-D68 from GenBank were analyzed with phylodynamics approaches.Results: Sharp bottlenecks of viral population dynamics in 2014 were observed to be strongly correlated with pandemic prevalence of EV-D68; multi-clade distribution of EV-D68 in the USA and Germany in the time-scaled maximum clade credibility tree of total EV-D68 was also a discriminative feature between pandemic and sporadic prevalences.Conclusion: These findings provide insights into the phylogenetic features of EV-D68 correlated with its differential epidemiological patterns among continents.