Modulation of gene expression in Kaposi's sarcoma-associated herpesvirus-infected lymphoid and epithelial cells. (September 2016)

• Record Type: Journal Article
• Authors: Matteoli, Barbara; Broccolo, Francesco; Oggioni, Massimo; Scaccino, Antonio; Formica, Francesco; Ciccarese, Giulia; Drago, Francesco; Fusetti, Lisa; Esposito, Susanna; Ceccherini-Nelli, Luca
• Is Part Of: Future virology. Volume 11:Number 9(2016)
• Page Start: 619
• Page End: 629
• Publication Date: 2016-09
• Subjects: gene expression -- HHV-8 -- Kaposi's sarcoma; Virology -- Periodicals; Virus diseases -- Treatment -- Periodicals; 616.9101
• DOI: 10.2217/fvl-2016-0063
• Languages: English
• ISSNs: 1746-0794

Abstract

Aim: To evaluate the gene expression changes that occur soon after the active infection of two susceptible cell types with human herpesvirus 8 (HHV-8).Materials & methods: The expression profile of 282 human genes involved in the inflammatory process was investigated in HHV-8 A1 or C3 subtype-infected and mock-infected human epithelial cells and lymphoid cells.Results: The HHV-8-induced transcriptional profiles in the epithelial and lymphoid cells were very different. A robust increase in the expression was found in genes belonging to different categories, especially the categories of inflammation response and signal transduction.Conclusion: These results indicate that during early infection, HHV-8 induces a variety of cell type-specific processes, thus providing infection signatures useful as potential targets for therapeutic intervention.