A prospective study of enterovirus D68 in a regional UK center. (August 2016)

• Record Type: Journal Article
• Authors: Machin, Nicholas; Whitfield, Thomas; Mutton, Ken; Hesketh, Louise; Guiver, Malcolm; Turner, Andrew
• Is Part Of: Future virology. Volume 11:Number 8(2016)
• Page Start: 571
• Page End: 576
• Publication Date: 2016-08
• Subjects: clinical features -- enterovirus D68 -- epidemiology -- EV-D68 -- immunocompromised -- infection -- pediatric -- phylogenetic analysis -- respiratory; Virology -- Periodicals; Virus diseases -- Treatment -- Periodicals; 616.9101
• DOI: 10.2217/fvl-2016-0036
• Languages: English
• ISSNs: 1746-0794

Abstract

Aim: A prospective study was undertaken to establish the prevalence of enterovirus D68 (EV-D68) in the northwest of England.Patients & samples: In the period 24 October through 31 December 2014, respiratory samples were screened by a specific real-time PCR and EV-D68 was identified by nucleotide sequence-based typing.Results: Enterovirus was detected in 7.4% of samples and EV-D68 was confirmed in 32 cases. Phylogenetic analysis showed that EV-D68 strains corresponded to clades A and B. Clinical presentation of cases ranged from mild to severe respiratory infection. The majority of cases had comorbidities that might predispose to severe infection.Conclusion: EV-D68 was circulating in our region during late 2014 and has the potential to cause severe disease.